Cited 59 times in
PM2.5 concentration in the ambient air is a risk factor for the development of high-risk coronary plaques
DC Field | Value | Language |
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dc.contributor.author | 장혁재 | - |
dc.date.accessioned | 2020-02-11T06:37:54Z | - |
dc.date.available | 2020-02-11T06:37:54Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 2047-2404 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/174759 | - |
dc.description.abstract | AIMS: We aimed to investigate whether long-term exposure to particulate matter with an aerodynamic diameter <2.5 μm (PM2.5) in the ambient air is related to the development or growth of coronary plaques. METHODS AND RESULTS: This study involved 364 residents of Seoul, Korea, who underwent serial coronary computed tomographic angiography (CCTA) at an interval of ≥2 years. Each participant's average concentration of residential PM2.5 between the two CCTAs was calculated. Primary endpoint was the development of high-risk plaque (HRP), defined as a plaque with low attenuation, spotty calcium, and positive remodelling. Secondary endpoints were the volume increase of total plaque and its component volume. Among those without HRP at baseline (n = 341), 20 patients developed HRP at follow-up CCTA, the residential PM2.5 concentration of which was significantly higher than those without HRP at follow-up (25.8 ± 2.0 vs. 25.0 ± 1.7 μg/m3 for patients with newly developed HRP vs. patients without HRP at follow-up; P = 0.047). An increase in PM2.5 concentration was associated with increased incidence of HRP at follow-up [adjusted hazard ratio (aHR) 1.62, 95% confidence interval (CI) 1.22-2.15, P < 0.001]. In a secondary analysis, the PM2.5 concentration was associated with an increased risk of the formation of either fibrofatty or necrotic core component in newly developed plaques (aHR 1.41, 95% CI 1.23-1.61, P < 0.001), and with a higher risk of total plaque volume progression in the pre-existing plaques (aHR 1.14, 95% CI 1.05-1.23, P = 0.002). CONCLUSION: Exposure to higher concentration of PM2.5 in the ambient air is significantly associated with the development of high-risk coronary plaques. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Oxford University Press | - |
dc.relation.isPartOf | EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | PM2.5 concentration in the ambient air is a risk factor for the development of high-risk coronary plaques | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Seokhun Yang | - |
dc.contributor.googleauthor | Seung-Pyo Lee | - |
dc.contributor.googleauthor | Jun-Bean Park | - |
dc.contributor.googleauthor | Heesun Lee | - |
dc.contributor.googleauthor | Si-Hyuck Kang | - |
dc.contributor.googleauthor | Sang-Eun Lee | - |
dc.contributor.googleauthor | Juyong Brian Kim | - |
dc.contributor.googleauthor | Su-Yeon Choi | - |
dc.contributor.googleauthor | Yong-Jin Kim | - |
dc.contributor.googleauthor | Hyuk-Jae Chang | - |
dc.identifier.doi | 10.1093/ehjci/jez209 | - |
dc.contributor.localId | A03490 | - |
dc.relation.journalcode | J00806 | - |
dc.identifier.eissn | 2047-2412 | - |
dc.identifier.pmid | 31410457 | - |
dc.identifier.url | https://academic.oup.com/ehjcimaging/article/20/12/1355/5549446 | - |
dc.subject.keyword | air pollution | - |
dc.subject.keyword | atherosclerosis | - |
dc.subject.keyword | atherosclerotic plaque | - |
dc.subject.keyword | coronary artery disease | - |
dc.subject.keyword | particulate matter | - |
dc.contributor.alternativeName | Chang, Hyuck Jae | - |
dc.contributor.affiliatedAuthor | 장혁재 | - |
dc.citation.volume | 20 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1355 | - |
dc.citation.endPage | 1364 | - |
dc.identifier.bibliographicCitation | EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, Vol.20(12) : 1355-1364, 2019 | - |
dc.identifier.rimsid | 63463 | - |
dc.type.rims | ART | - |
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