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Inverse associations of bisphenol A and phthalate metabolites with serum bilirubin levels in Korean population

Authors
 Yoonjeong Choi  ;  Sun Ju Lee  ;  Jooeun Jeon  ;  Keum Ji Jung  ;  Sun Ha Jee 
Citation
 ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, Vol.26(26) : 26685-26695, 2019 
Journal Title
 ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 
ISSN
 0944-1344 
Issue Date
2019
MeSH
Adult ; Aged ; Benzhydryl Compounds/blood ; Benzhydryl Compounds/urine* ; Bilirubin/blood* ; Cross-Sectional Studies ; Endocrine Disruptors/adverse effects ; Endocrine Disruptors/blood ; Endocrine Disruptors/urine ; Environmental Biomarkers ; Environmental Exposure/adverse effects ; Environmental Exposure/analysis ; Environmental Pollutants/analysis* ; Environmental Pollutants/metabolism ; Female ; Humans ; Linear Models ; Male ; Middle Aged ; Oxidative Stress ; Phenols/blood ; Phenols/urine* ; Phthalic Acids/blood ; Phthalic Acids/metabolism ; Phthalic Acids/urine* ; Republic of Korea
Keywords
Bilirubin ; Bisphenol ; Endocrine disruptors ; Inverse association ; Linear models ; Phthalate
Abstract
Bisphenol A (BPA) and phthalates are endocrine disruptors that can induce oxidative stress. Serum bilirubin has antioxidant properties and may serve as a biomarker of oxidative stress. The objective of this study was to explore the relationship of BPA and phthalates with serum bilirubin levels in a Korean population. Urinary concentrations of BPA and six phthalate [mono-n-butyl phthalate (MnBP), mono-iso-butyl phthalate (MiBP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono-(2-ethyl-5- hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), and mono-benzyl phthalate (MBzP)] were measured in 709 participants. Serum concentrations of BPA and three phthalate metabolites [MnBP, MiBP, and mono-(2-ethylhexyl) phthalate (MEHP)] were measured in 752 participants. After excluding missing variables, associations between above chemicals and serum bilirubin levels were analyzed using multivariate linear regression with age, sex, BMI, GGT, GOT, GPT, and alcohol intake adjustment. Participants were further stratified by sex. Among the urinary chemicals, BPA and four phthalate metabolites (MnBP, MEOHP, MEHHP and MECPP) were inversely associated with serum bilirubin levels (BPA: β = - 0.071, P < 0.0001; MnBP: β = - 0.055, P = 0.025; MEOHP: β = - 0.101, P < 0.0001; MEHHP: β = - 0.106, P < 0.0001; MECPP: β = - 0.052, P = 0.003). In a case of serum chemicals, only MiBP showed significantly positive association (β = 0.036, P = 0.016). After stratification by sex, the associations of urinary BPA remained both in male and female, of which urinary phthalates disappeared in female. The association of serum MiBP was disappeared after stratification. Urinary BPA and phthalate metabolites were inversely associated with serum bilirubin levels, whereas serum MiBP showed positive association with bilirubin. These results could provide clues for understanding the mechanisms of endocrine disruptor from oxidative stress to excretion from our body.
Full Text
https://link.springer.com/article/10.1007%2Fs11356-019-05205-y
DOI
10.1007/s11356-019-05205-y
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Lee, Sun Ju(이선주) ORCID logo https://orcid.org/0000-0002-6582-8795
Jung, Keum Ji(정금지) ORCID logo https://orcid.org/0000-0003-4993-0666
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
Choi, Yoon Jung(최윤정)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174751
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