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Bioactive characteristics of an implant surface coated with a pH buffering agent: an in vitro study

Authors
 Hyung-Chul Pae  ;  Su-Kyoung Kim  ;  Jin-Young Park  ;  Young Woo Song  ;  Jae-Kook Cha  ;  Jeong-Won Paik  ;  Seong-Ho Choi 
Citation
 JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE, Vol.49(6) : 366-381, 2019 
Journal Title
 JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE 
ISSN
 2093-2278 
Issue Date
2019
Keywords
Biocompatible coated materials ; Dental implants ; Immunoassay ; Surface properties
Abstract
Purpose: The purpose of this study was to evaluate the effectiveness of conventional sandblasted, large-grit, acid-etched (SLA) surface coated with a pH buffering solution based on surface wettability, blood protein adhesion, osteoblast affinity, and platelet adhesion and activation. Methods: Titanium discs and implants with conventional SLA surface (SA), SLA surface in an aqueous calcium chloride solution (CA), and SLA surface with a pH buffering agent (SOI) were prepared. The wetting velocity was measured by the number of threads wetted by blood over an interval of time. Serum albumin adsorption was tested using the bicinchoninic acid assay and by measuring fluorescence intensity. Osteoblast activity assays (osteoblast adhesion, proliferation, differentiation, mineralization, and migration) were also performed, and platelet adhesion and activation assays were conducted. Results: In both the wetting velocity test and the serum albumin adsorption assay, the SOI surface displayed a significantly higher wetting velocity than the SA surface (P=0.000 and P=0.000, respectively). In the osteoblast adhesion, proliferation, differentiation, and mineralization tests, the mean values for SOI were all higher than those for SA and CA. On the osteoblast migration, platelet adhesion, and activation tests, SOI also showed significantly higher values than SA (P=0.040, P=0.000, and P=0.000, respectively). Conclusions: SOI exhibited higher hydrophilicity and affinity for proteins, cells, and platelets than SA. Within the limits of this study, it may be concluded that coating an implant with a pH buffering agent can induce the attachment of platelets, proteins, and cells to the implant surface. Further studies should be conducted to directly compare SOI with other conventional surfaces with regard to its safety and effectiveness in clinical settings.
Files in This Item:
T201905252.pdf Download
DOI
10.5051/jpis.2019.49.6.366
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Pae, Hyung-Chul(배형철) ORCID logo https://orcid.org/0000-0002-6365-3557
Paik, Jeong Won(백정원) ORCID logo https://orcid.org/0000-0002-5554-8503
Song, Young Woo(송영우) ORCID logo https://orcid.org/0000-0003-1835-5646
Cha, Jae Kook(차재국) ORCID logo https://orcid.org/0000-0001-6817-9834
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174690
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