Cited 7 times in
Transplant outcomes in positive complement-dependent cytotoxicity- versus flow cytometry-crossmatch kidney transplant recipients after successful desensitization: a retrospective study
DC Field | Value | Language |
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dc.contributor.author | 김덕기 | - |
dc.contributor.author | 김명수 | - |
dc.contributor.author | 김범석 | - |
dc.contributor.author | 김순일 | - |
dc.contributor.author | 김유선 | - |
dc.contributor.author | 박윤희 | - |
dc.contributor.author | 이주한 | - |
dc.contributor.author | 정현주 | - |
dc.contributor.author | 허규하 | - |
dc.date.accessioned | 2020-02-11T06:26:17Z | - |
dc.date.available | 2020-02-11T06:26:17Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/174677 | - |
dc.description.abstract | BACKGROUND: Despite the obvious survival benefit compared to that among waitlist patients, outcomes of positive crossmatch kidney transplantation (KT) are generally inferior to those of human leukocyte antigen (HLA)-compatible KT. This study aimed to compare the outcomes of positive complement-dependent cytotoxicity (CDC) crossmatch (CDC + FC+) and positive flow cytometric crossmatch (CDC-FC+) with those of HLA-compatible KT (CDC-FC-) after successful desensitization. METHODS: We retrospectively analyzed 330 eligible patients who underwent KTs between June 2011 and August 2017: CDC-FC- (n = 274), CDC-FC+ (n = 39), and CDC + FC+ (n = 17). Desensitization protocol targeting donor-specific antibody (DSA) involved plasmapheresis, intravenous immunoglobulin (IVIG), and rituximab with/without bortezomib for positive-crossmatch KT. RESULTS: Death-censored graft survival and patient survival were not different among the three groups. The median estimated glomerular filtration rate was significantly lower in the CDC + FC+ group than in the compatible group at 6 months (P < 0.001) and 2 years (P = 0.020). Biopsy-proven rejection within 1 year of CDC-FC-, CDC-FC+, and CDC + FC+ were 15.3, 28.2, and 47.0%, respectively. Urinary tract infections (P < 0.001), Pneumocystis jirovecii pneumonia (P < 0.001), and cytomegalovirus viremia (P < 0.001) were more frequent in CDC-FC+ and CDC + FC+ than in CDC-FC-. CONCLUSIONS: This study showed that similar graft and patient survival was achieved in CDC-FC+ and CDC + FC+ KT compared with CDC-FC- through DSA-targeted desensitization despite the higher incidence of rejection and infection than that in compatible KT. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | BioMed Central | - |
dc.relation.isPartOf | BMC NEPHROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Transplant outcomes in positive complement-dependent cytotoxicity- versus flow cytometry-crossmatch kidney transplant recipients after successful desensitization: a retrospective study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Deok Gie Kim | - |
dc.contributor.googleauthor | Juhan Lee | - |
dc.contributor.googleauthor | Younhee Park | - |
dc.contributor.googleauthor | Myoung Soo Kim | - |
dc.contributor.googleauthor | Hyeon Joo Jeong | - |
dc.contributor.googleauthor | Soon Il Kim | - |
dc.contributor.googleauthor | Yu Seun Kim | - |
dc.contributor.googleauthor | Beom Seok Kim | - |
dc.contributor.googleauthor | Kyu Ha Huh | - |
dc.identifier.doi | 10.1186/s12882-019-1625-2 | - |
dc.contributor.localId | A05303 | - |
dc.contributor.localId | A00424 | - |
dc.contributor.localId | A00488 | - |
dc.contributor.localId | A00649 | - |
dc.contributor.localId | A00785 | - |
dc.contributor.localId | A01606 | - |
dc.contributor.localId | A03163 | - |
dc.contributor.localId | A03771 | - |
dc.contributor.localId | A04344 | - |
dc.relation.journalcode | J00367 | - |
dc.identifier.eissn | 1471-2369 | - |
dc.identifier.pmid | 31818254 | - |
dc.subject.keyword | Desensitization | - |
dc.subject.keyword | Donor-specific antibody | - |
dc.subject.keyword | Kidney transplantation | - |
dc.subject.keyword | Positive crossmatch | - |
dc.contributor.alternativeName | Kim, Deok Gie | - |
dc.contributor.affiliatedAuthor | 김덕기 | - |
dc.contributor.affiliatedAuthor | 김명수 | - |
dc.contributor.affiliatedAuthor | 김범석 | - |
dc.contributor.affiliatedAuthor | 김순일 | - |
dc.contributor.affiliatedAuthor | 김유선 | - |
dc.contributor.affiliatedAuthor | 박윤희 | - |
dc.contributor.affiliatedAuthor | 이주한 | - |
dc.contributor.affiliatedAuthor | 정현주 | - |
dc.contributor.affiliatedAuthor | 허규하 | - |
dc.citation.volume | 20 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 456 | - |
dc.identifier.bibliographicCitation | BMC NEPHROLOGY, Vol.20(1) : 456, 2019 | - |
dc.identifier.rimsid | 63409 | - |
dc.type.rims | ART | - |
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