Cited 11 times in
Long-term prognostic utility of computed tomography coronary angiography in older populations
DC Field | Value | Language |
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dc.contributor.author | 장혁재 | - |
dc.date.accessioned | 2020-02-11T06:16:07Z | - |
dc.date.available | 2020-02-11T06:16:07Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 2047-2404 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/174609 | - |
dc.description.abstract | AIMS: The long-term prognostic value of coronary computed tomography angiography (CCTA)-identified coronary artery disease (CAD) has not been evaluated in elderly patients (≥70 years). We compared the ability of coronary CCTA to predict 5-year mortality in older vs. younger populations. METHODS AND RESULTS: From the prospective CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) registry, we analysed CCTA results according to age <70 years (n = 7198) vs. ≥70 years (n = 1786). The severity of CAD was classified according to: (i) maximal stenosis degree per vessel: none, non-obstructive (1-49%), or obstructive (>50%); (ii) segment involvement score (SIS): number of segments with plaque. Cox-proportional hazard models assessed the relationship between CCTA findings and time to mortality. At a mean 5.6 ± 1.1 year follow-up, CCTA-identified CAD predicted increased mortality compared with patients with a normal CCTA in both <70 years [non-obstructive hazard ratio (HR) confidence interval (CI): 1.70 (1.19-2.41); one-vessel: 1.65 (1.03-2.67); two-vessel: 2.24 (1.21-4.15); three-vessel/left main: 4.12 (2.27-7.46), P < 0.001] and ≥70 years [non-obstructive: 1.84 (1.15-2.95); one-vessel: HR (CI): 2.28 (1.37-3.81); two-vessel: 2.36 (1.33-4.19); three-vessel/left main: 2.41 (1.33-4.36), P = 0.014]. Similarly, SIS was predictive of mortality in both <70 years [SIS 1-3: 1.57 (1.10-2.24); SIS ≥4: 2.42 (1.65-3.57), P < 0.001] and ≥70 years [SIS 1-3: 1.73 (1.07-2.79); SIS ≥4: 2.45 (1.52-3.93), P < 0.001]. CCTA findings similarly predicted long-term major adverse cardiovascular outcomes (MACE) (all-cause mortality, myocardial infarction, and late revascularization) in both groups compared with patients with no CAD. CONCLUSION: The presence and extent of CAD is a meaningful stratifier of long-term mortality and MACE in patients aged <70 years and ≥70 years old. The presence of obstructive and non-obstructive disease and the burden of atherosclerosis determined by SIS remain important predictors of prognosis in older populations. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Oxford University Press | - |
dc.relation.isPartOf | EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Long-term prognostic utility of computed tomography coronary angiography in older populations | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Sonali R. Gnanenthiran | - |
dc.contributor.googleauthor | Christopher Naoum | - |
dc.contributor.googleauthor | Jonathon A. Leipsic | - |
dc.contributor.googleauthor | Stephan Achenbach | - |
dc.contributor.googleauthor | Mouaz H. Al-Mallah | - |
dc.contributor.googleauthor | Daniele Andreini | - |
dc.contributor.googleauthor | Jeroen J. Bax | - |
dc.contributor.googleauthor | Daniel S. Berman | - |
dc.contributor.googleauthor | Matthew J. Budoff | - |
dc.contributor.googleauthor | Filippo Cademartiri | - |
dc.contributor.googleauthor | Tracy Q. Callister | - |
dc.contributor.googleauthor | Hyuk-Jae Chang | - |
dc.contributor.googleauthor | Kavitha Chinnaiyan | - |
dc.contributor.googleauthor | Benjamin J.W. Chow | - |
dc.contributor.googleauthor | Ricardo C. Cury | - |
dc.contributor.googleauthor | Augustin DeLago | - |
dc.contributor.googleauthor | Gudrun Feuchtner | - |
dc.contributor.googleauthor | Martin Hadamitzky | - |
dc.contributor.googleauthor | Joerg Hausleiter | - |
dc.contributor.googleauthor | Philipp A. Kaufman | - |
dc.contributor.googleauthor | Yong-Jin Kim | - |
dc.contributor.googleauthor | Erica Maffei | - |
dc.contributor.googleauthor | Hugo Marques | - |
dc.contributor.googleauthor | Pedro de Arau´ jo Gonc¸alves | - |
dc.contributor.googleauthor | Gianluca Pontone | - |
dc.contributor.googleauthor | Gilbert L. Raff | - |
dc.contributor.googleauthor | Ronen Rubinshtein | - |
dc.contributor.googleauthor | Leslee J. Shaw | - |
dc.contributor.googleauthor | Todd C. Villines | - |
dc.contributor.googleauthor | Heidi Gransar | - |
dc.contributor.googleauthor | Yao Lu | - |
dc.contributor.googleauthor | Erica C. Jones | - |
dc.contributor.googleauthor | Jessica M. Pe~na | - |
dc.contributor.googleauthor | Fay Y. Lin | - |
dc.contributor.googleauthor | Leonard Kritharides | - |
dc.contributor.googleauthor | James K. Min | - |
dc.identifier.doi | 10.1093/ehjci/jez067 | - |
dc.contributor.localId | A03490 | - |
dc.relation.journalcode | J00806 | - |
dc.identifier.eissn | 2047-2412 | - |
dc.identifier.pmid | 30993334 | - |
dc.identifier.url | https://academic.oup.com/ehjcimaging/article/20/11/1279/5472788 | - |
dc.subject.keyword | age | - |
dc.subject.keyword | coronary computed tomography angiography | - |
dc.subject.keyword | major adverse cardiovascular events | - |
dc.subject.keyword | mortality | - |
dc.subject.keyword | older populations | - |
dc.contributor.alternativeName | Chang, Hyuck Jae | - |
dc.contributor.affiliatedAuthor | 장혁재 | - |
dc.citation.volume | 20 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1279 | - |
dc.citation.endPage | 1286 | - |
dc.identifier.bibliographicCitation | EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, Vol.20(11) : 1279-1286, 2019 | - |
dc.identifier.rimsid | 63560 | - |
dc.type.rims | ART | - |
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