Cited 3 times in
PRavastatin Versus FlUVastatin After Statin Intolerance: The PRUV-Intolerance Study With Propensity Score Matching
DC Field | Value | Language |
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dc.contributor.author | 강석민 | - |
dc.contributor.author | 고영국 | - |
dc.contributor.author | 김병극 | - |
dc.contributor.author | 김중선 | - |
dc.contributor.author | 박성하 | - |
dc.contributor.author | 심지영 | - |
dc.contributor.author | 안철민 | - |
dc.contributor.author | 오재원 | - |
dc.contributor.author | 이상학 | - |
dc.contributor.author | 이찬주 | - |
dc.contributor.author | 장양수 | - |
dc.contributor.author | 장혁재 | - |
dc.contributor.author | 전경현 | - |
dc.contributor.author | 최동훈 | - |
dc.contributor.author | 하종원 | - |
dc.contributor.author | 홍그루 | - |
dc.contributor.author | 홍명기 | - |
dc.date.accessioned | 2020-02-11T06:13:38Z | - |
dc.date.available | 2020-02-11T06:13:38Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0002-9343 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/174593 | - |
dc.description.abstract | BACKGROUND: Limited data are available on the relapse of statin intolerance after resumption of statins. We aimed to evaluate the relapse rates of statin intolerance in patients who subsequently received pravastatin or fluvastatin and to identify associated factors. METHODS: This retrospective, propensity score-matched cohort study screened data obtained from a tertiary university hospital between 2006 and 2015. Of 8073 patients screened, 488 with statin intolerance who received pravastatin or fluvastatin with regular follow-up were enrolled. After propensity score matching of patients, 384 were finally analyzed. The primary outcome variables were relapse of statin intolerance and stopping (ie, discontinuation or switching to other statins) rate for the 2 statins. RESULTS: During the median follow-up period of 37 months, the rate of relapse of intolerance was 10.4% and 18.2% among users of pravastatin and fluvastatin, respectively (P = 0.04). However, the log-rank test showed no difference in the relapse-free rates between the 2 groups (P = 0.34). The stopping rates of the 2 statins were 36.5% and 42.2% (P = 0.30), respectively, for various reasons, including low efficacy of the drugs. After adjustment, chronic kidney disease (hazard ratio [HR] 1.83, P = 0.03) and previous creatine kinase elevation (HR 3.13, P = 0.001) were identified as independent determinants of relapse. Older age (HR 1.03, P = 0.057) and female sex (HR 1.70, P = 0.059) were associated, but not significantly, with relapse. CONCLUSION: Although a small proportion of patients taking pravastatin or fluvastatin experienced a relapse of intolerance, many patients eventually discontinued or changed these agents. Chronic kidney disease and history of creatine kinase elevation were independent determinants of relapse. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Excerpta Medica | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | PRavastatin Versus FlUVastatin After Statin Intolerance: The PRUV-Intolerance Study With Propensity Score Matching | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Ji Woong Roh | - |
dc.contributor.googleauthor | Kyeong-Hyeon Chun | - |
dc.contributor.googleauthor | Moonjong Kang | - |
dc.contributor.googleauthor | Chan Joo Lee | - |
dc.contributor.googleauthor | Jaewon Oh | - |
dc.contributor.googleauthor | Chi-Young Shim | - |
dc.contributor.googleauthor | Chul-Min Ahn | - |
dc.contributor.googleauthor | Jung-Sun Kim | - |
dc.contributor.googleauthor | Byeong-Keuk Kim | - |
dc.contributor.googleauthor | Sungha Park | - |
dc.contributor.googleauthor | Hyuk-Jae Chang | - |
dc.contributor.googleauthor | Geu-Ru Hong | - |
dc.contributor.googleauthor | Young-Guk Ko | - |
dc.contributor.googleauthor | Seok-Min Kang | - |
dc.contributor.googleauthor | Donghoon Choi | - |
dc.contributor.googleauthor | Jong-Won Ha | - |
dc.contributor.googleauthor | Myeong-Ki Hong | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Sang-Hak Lee | - |
dc.identifier.doi | 10.1016/j.amjmed.2019.06.003 | - |
dc.contributor.localId | A00037 | - |
dc.contributor.localId | A00127 | - |
dc.contributor.localId | A00493 | - |
dc.contributor.localId | A00961 | - |
dc.contributor.localId | A01512 | - |
dc.contributor.localId | A02213 | - |
dc.contributor.localId | A02269 | - |
dc.contributor.localId | A02395 | - |
dc.contributor.localId | A02833 | - |
dc.contributor.localId | A03238 | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A03490 | - |
dc.contributor.localId | A03500 | - |
dc.contributor.localId | A04053 | - |
dc.contributor.localId | A04257 | - |
dc.contributor.localId | A04386 | - |
dc.contributor.localId | A04391 | - |
dc.relation.journalcode | J00093 | - |
dc.identifier.eissn | 1555-7162 | - |
dc.identifier.pmid | 31278931 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0002934319305388 | - |
dc.subject.keyword | Asian continental ancestry group | - |
dc.subject.keyword | Hydroxymethylglutaryl coA reductases | - |
dc.subject.keyword | Hypercholesterolemia | - |
dc.subject.keyword | Safety | - |
dc.contributor.alternativeName | Kang, Seok Min | - |
dc.contributor.affiliatedAuthor | 강석민 | - |
dc.contributor.affiliatedAuthor | 고영국 | - |
dc.contributor.affiliatedAuthor | 김병극 | - |
dc.contributor.affiliatedAuthor | 김중선 | - |
dc.contributor.affiliatedAuthor | 박성하 | - |
dc.contributor.affiliatedAuthor | 심지영 | - |
dc.contributor.affiliatedAuthor | 안철민 | - |
dc.contributor.affiliatedAuthor | 오재원 | - |
dc.contributor.affiliatedAuthor | 이상학 | - |
dc.contributor.affiliatedAuthor | 이찬주 | - |
dc.contributor.affiliatedAuthor | 장양수 | - |
dc.contributor.affiliatedAuthor | 장혁재 | - |
dc.contributor.affiliatedAuthor | 전경현 | - |
dc.contributor.affiliatedAuthor | 최동훈 | - |
dc.contributor.affiliatedAuthor | 하종원 | - |
dc.contributor.affiliatedAuthor | 홍그루 | - |
dc.contributor.affiliatedAuthor | 홍명기 | - |
dc.citation.volume | 132 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1320 | - |
dc.citation.endPage | 1326 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF MEDICINE, Vol.132(11) : 1320-1326, 2019 | - |
dc.identifier.rimsid | 63585 | - |
dc.type.rims | ART | - |
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