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Therapeutic Hypothermia and Neuroprotection in Acute Neurological Disease

Authors
 Kota Kurisu  ;  Jong Youl Kim  ;  Jesung You  ;  Midori A. Yenari 
Citation
 CURRENT MEDICINAL CHEMISTRY, Vol.26(29) : 5430-5455, 2019 
Journal Title
 CURRENT MEDICINAL CHEMISTRY 
ISSN
 0929-8673 
Issue Date
2019
Keywords
Hypothermia ; cardiac arrest ; hypoxic- ischemic encephalopathy ; pharmacology induced hypothermia ; stroke ; traumatic brain injury
Abstract
Therapeutic hypothermia has consistently been shown to be a robust neuroprotectant in many labs studying different models of neurological disease. Although this therapy has shown great promise, there are still challenges at the clinical level that limit the ability to apply this routinely to each pathological condition. In order to overcome issues involved in hypothermia therapy, understanding of this attractive therapy is needed. We review methodological concerns surrounding therapeutic hypothermia, introduce the current status of therapeutic cooling in various acute brain insults, and review the literature surrounding the many underlying molecular mechanisms of hypothermic neuroprotection. Because recent work has shown that body temperature can be safely lowered using pharmacological approaches, this method may be an especially attractive option for many clinical applications. Since hypothermia can affect multiple aspects of brain pathophysiology, therapeutic hypothermia could also be considered a neuroprotection model in basic research, which would be used to identify potential therapeutic targets. We discuss how research in this area carries the potential to improve outcome from various acute neurological disorders.
Files in This Item:
T201904868.pdf Download
DOI
10.2174/0929867326666190506124836
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jong Youl(김종열) ORCID logo https://orcid.org/0000-0002-8340-2894
You, Je Sung(유제성) ORCID logo https://orcid.org/0000-0002-2074-6745
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174557
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