Cited 8 times in
Effect of polygenic load on striatal dopaminergic deterioration in Parkinson disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 류철형 | - |
dc.date.accessioned | 2020-02-11T02:23:10Z | - |
dc.date.available | 2020-02-11T02:23:10Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0028-3878 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/174494 | - |
dc.description.abstract | OBJECTIVE: To investigate the effect of polygenic load on the progression of striatal dopaminergic dysfunction in patients with Parkinson disease (PD). METHODS: Using data from 335 patients with PD in the Parkinson's Progression Markers Initiative (PPMI) database, we investigated the longitudinal association of PD-associated polygenic load with changes in striatal dopaminergic activity as measured by 123I-N-3-fluoropropyl-2-β-carboxymethoxy-3β-(4-iodophenyl) nortropane (123I-FP-CIT) SPECT over 4 years. PD-associated polygenic load was estimated by calculating weighted genetic risk scores (GRS) using 1) all available 27 PD-risk single nucleotide polymorphisms (SNPs) in the PPMI database (GRS1) and 2) 23 SNPs with minor allele frequency >0.05 (GRS2). RESULTS: GRS1 and GRS2 were correlated with younger age at onset in patients with PD (GRS1, Spearman ρ = -0.128, p = 0.019; GRS2, Spearman ρ = -0.109, p = 0.047). Although GRS1 did not show an association with changes in striatal 123I-FP-CIT availability, GRS2 was associated with a slower decline of striatal dopaminergic activity (interactions with disease duration in linear mixed model; caudate nucleus, estimate = 0.399, SE = 0.165, p = 0.028; putamen, estimate = 0.396, SE = 0.137, p = 0.016). CONCLUSIONS: Our results suggest that genetic factors for PD risk may have heterogeneous effects on striatal dopaminergic degeneration, and some factors may be associated with a slower decline of dopaminergic activity. Composition of PD progression-specific GRS may be useful in predicting disease progression in patients. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | NEUROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Caudate Nucleus/metabolism | - |
dc.subject.MESH | Corpus Striatum/metabolism* | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Dopamine Plasma Membrane Transport Proteins/metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Parkinson Disease/complications | - |
dc.subject.MESH | Parkinson Disease/genetics | - |
dc.subject.MESH | Parkinson Disease/metabolism* | - |
dc.subject.MESH | Parkinsonian Disorders/complications | - |
dc.subject.MESH | Parkinsonian Disorders/metabolism* | - |
dc.subject.MESH | Putamen/metabolism | - |
dc.subject.MESH | Tropanes/metabolism* | - |
dc.title | Effect of polygenic load on striatal dopaminergic deterioration in Parkinson disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Myung Jun Lee | - |
dc.contributor.googleauthor | Kyoungjune Pak | - |
dc.contributor.googleauthor | Jong Hun Kim | - |
dc.contributor.googleauthor | Yun Joong Kim | - |
dc.contributor.googleauthor | Jeehee Yoon | - |
dc.contributor.googleauthor | Jinwoo Lee | - |
dc.contributor.googleauthor | Chul Hyoung Lyoo | - |
dc.contributor.googleauthor | Hyung Jun Park | - |
dc.contributor.googleauthor | Jae-Hyeok Lee | - |
dc.contributor.googleauthor | Na-Yeon Jung | - |
dc.identifier.doi | 10.1212/WNL.0000000000007939 | - |
dc.contributor.localId | A01333 | - |
dc.relation.journalcode | J02340 | - |
dc.identifier.eissn | 1526-632X | - |
dc.identifier.pmid | 31289143 | - |
dc.identifier.url | https://n.neurology.org/content/93/7/e665.long | - |
dc.contributor.alternativeName | Lyoo, Chul Hyoung | - |
dc.contributor.affiliatedAuthor | 류철형 | - |
dc.citation.volume | 93 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | e665 | - |
dc.citation.endPage | e674 | - |
dc.identifier.bibliographicCitation | NEUROLOGY, Vol.93(7) : e665-e674, 2019 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.