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신생아 호흡곤란 증후군에서 국내 개발된 Bovine Lung Surfactant YY-38 보충요법의 임상 효과
DC Field | Value | Language |
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dc.contributor.author | 남궁란 | - |
dc.contributor.author | 박국인 | - |
dc.contributor.author | 박민수 | - |
dc.contributor.author | 이철 | - |
dc.date.accessioned | 2020-01-23T05:37:23Z | - |
dc.date.available | 2020-01-23T05:37:23Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0560-3560 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/174414 | - |
dc.description.abstract | Purpose : We previously reported modified bovine lung surfactant YY-38(NewfactanⓇ) had a low surface tension, good hysteresis, and exhibited good pressure-volume curve in animal experiment (J Korean Pediatr Asso 1997;40:771-85). We performed multicenter clinical trial of NewfactanⓇ in neonatal RDS. Methods : Seventy-seven infants with RDS(GA 31.8¡¾2.9 wks and BW 1,809¡¾592 gm) in 4 NICU were enrolled. After administration of NewfactanⓇ, we analyzed ventilator parameters and outcomes in 71 infants excluding mortality cases(n=6), and also compared risk factors between response(n=53) and redosing group(n=18). Results : NewfactanⓇ was administered at 6.8¡¾7.2 hr after birth. Ventilator parameters such as FiO2, alveolar-arterial oxygen difference(a-A PO2) and oxygenation index(OI) except mean airway pressure(MAP) were significantly improved from six hours after administration. All parameters were improved at 24 hours after administration and persisted for 5 days. Outcomes were as follows; PDA(n=24), BPD(n=16), IVH(n=13), sepsis(n=9), ROP(n=7), pneumothorax(n=4) NEC(n=3), PIE(n=2), and pulmonary hemorrhage(n=1). All patients survived 30 days after birth. Redosing rate was 25%. The incidence of PDA was greater in redosing(56%) than in response group(26 %)(P=0.025). Conclusion : In prospective multicenter clinical trial, NewfactanⓇ was effective in the treatment of RDS. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한소아과학회 | - |
dc.relation.isPartOf | Journal of the Korean Pediatric Association (소아과) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 신생아 호흡곤란 증후군에서 국내 개발된 Bovine Lung Surfactant YY-38 보충요법의 임상 효과 | - |
dc.title.alternative | Clinical Trial of Domestically Developed Bovine Lung Surfactant YY-38 in Neonatal Respiratory Distress Syndrome | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아청소년과학교실) | - |
dc.contributor.googleauthor | 이철 | - |
dc.contributor.googleauthor | 김정년 | - |
dc.contributor.googleauthor | 박민수 | - |
dc.contributor.googleauthor | 박문성 | - |
dc.contributor.googleauthor | 윤신원 | - |
dc.contributor.googleauthor | 장욱 | - |
dc.contributor.googleauthor | 남궁란 | - |
dc.contributor.googleauthor | 박국인 | - |
dc.contributor.googleauthor | 한동관 | - |
dc.contributor.localId | A01241 | - |
dc.contributor.localId | A01438 | - |
dc.contributor.localId | A01468 | - |
dc.contributor.localId | A03253 | - |
dc.relation.journalcode | J01842 | - |
dc.subject.keyword | Clinical | - |
dc.subject.keyword | Modified bovine lung surfactant | - |
dc.subject.keyword | Newfactan | - |
dc.subject.keyword | Respiratory distress syndrome | - |
dc.contributor.alternativeName | Namgung, Ran | - |
dc.contributor.affiliatedAuthor | 남궁란 | - |
dc.contributor.affiliatedAuthor | 박국인 | - |
dc.contributor.affiliatedAuthor | 박민수 | - |
dc.contributor.affiliatedAuthor | 이철 | - |
dc.citation.volume | 42 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 472 | - |
dc.citation.endPage | 483 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Pediatric Association (소아과), Vol.42(4) : 472-483, 1999 | - |
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