Cited 0 times in
유방암환자에서 종양 신생혈관형성과 bcl-2 발현과의 연관성
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정우희 | - |
dc.date.accessioned | 2020-01-23T05:30:03Z | - |
dc.date.available | 2020-01-23T05:30:03Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0496-6872 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/174336 | - |
dc.description.abstract | PURPOSE: To evaluate the prognostic significances of angiogenesis and bc1-2, and association of each other, we investigated the correlation of microvessel count for angiogenesis and bcl-2 expression in breast cancer. MATERIALS AND METHODS: We analysed immunohistochemistry staining from paraffin blocks in a series of 145 women with breast cancer. Immunohistochemical staining to detect factor VIII-related antigen highlighted the microvessels within primary invasive breast carcinoma. Using light microscopy, we counted microvessels per 200X field in the most active areas of neovascularization. To determine the bcl-2 immunoreactivity, we used a monoclonal antibody directed against the bcl-2 protein. RESULTS: The median of microvessel count (MVC) was 31.5, and the proportions of tumors with low and high MVC were 51% and 49%. Eighty (55.2%) cancers showed the bcl-2 immunoreactivity in the cytoplasm. The microvessel count were correlated with lymph node status (p <0.001), tumor size (p=0.001), and lymphatic invasion around tumor (p=0.009). bcl-2 expressions were corelated with estrogen receptor positivity (p<0.001) and progesterone recepter positivity (p=0.029). The microvessel counts were negatively correlated with bcl-2 expression (p=0.006). CONCLUSION: This study suggest that the angiogenesis which was investigated by micro- vessel counts was negatively correlated with bcl-2 expression. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한암학회 | - |
dc.relation.isPartOf | Journal of the Korean Cancer Association (대한암학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 유방암환자에서 종양 신생혈관형성과 bcl-2 발현과의 연관성 | - |
dc.title.alternative | Association of Tumor Angiogenesis with bcl - 2 Expression in Breast Cancer Patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | 김도일 | - |
dc.contributor.googleauthor | 이희대 | - |
dc.contributor.googleauthor | 정우희 | - |
dc.contributor.localId | A03671 | - |
dc.relation.journalcode | J01813 | - |
dc.subject.keyword | Beast cancer | - |
dc.subject.keyword | Angiogenesis | - |
dc.subject.keyword | bcl-2 | - |
dc.contributor.alternativeName | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | 정우희 | - |
dc.citation.volume | 31 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1159 | - |
dc.citation.endPage | 1167 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Cancer Association (대한암학회지), Vol.31(6) : 1159-1167, 1999 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.