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자궁경부암 세포의 증식에 관여하는 annexin-Ⅰ의 역할

DC FieldValueLanguage
dc.contributor.author김재훈-
dc.date.accessioned2020-01-23T05:28:32Z-
dc.date.available2020-01-23T05:28:32Z-
dc.date.issued1999-
dc.identifier.issn0494-4755-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/174313-
dc.description.abstractObjectives: To investigate the role of annexin-I in human cervical cancer, we evaluated the expression of annexin-I and the relation with the proliferation of cancer cells. Methods: By immunohistochemical analysis and the western blotting of annexin-I , we investigated the extent and distribution of the expression of annexin-I in cervical cancer tissues. After treating the human cancer cell lines ( SiHa and HeLa cell lines ) with tamoxifen, estradiol, and retinoic acid for 5 days to make the cells proliferate and antiproliferate, we measured the proliferation simultaneously with 3-(4,5- dimethyl thiazol- 2-yl)-2,5-diphenyl-tetr -azolium bromide (MTT) colorimetric assay and the expression level of annexin-I with flowcytometry. Results: In the immunohistochemical stains, a granular staining pattern involving the entire cytoplasm was more heavily observed in malignant lesions than in normals. In the western blotting, the antibodies against 35-kDa annexin-I appeared to react more strongly with the lysates of cancer tissues than normal and benign tissues. In SiHa and HeLa cell lines with tamoxifen and β- estradiol treatment, increased expressions of annexin-I were noted with correlated increased proliferation of cells, and with the treatments of all trans retinoic acid, decreased expressions of annexin-I were noted with correlated decreased proliferation of cells. Conclusions: The results suggest that the expression of annexin-I might correlate with cervical cancer than normal and the proliferation of cancer cells.-
dc.description.statementOfResponsibilityrestriction-
dc.languageKorean-
dc.publisher대한산부인과학회-
dc.relation.isPartOfKorean Journal of Obstetrics and Gynecology (대한산부인과학회잡지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.title자궁경부암 세포의 증식에 관여하는 annexin-Ⅰ의 역할-
dc.title.alternativeRole of annexin-I in cervical cancer cell proliferation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.googleauthor유영옥-
dc.contributor.googleauthor박태철-
dc.contributor.googleauthor남궁성은-
dc.contributor.googleauthor박동춘-
dc.contributor.googleauthor김재훈-
dc.contributor.googleauthor김대훈-
dc.contributor.googleauthor양용재-
dc.contributor.googleauthor이지현-
dc.contributor.googleauthor조성대-
dc.contributor.googleauthor조형권-
dc.contributor.localIdA00876-
dc.relation.journalcodeJ02075-
dc.identifier.urlhttp://kiss.kstudy.com/thesis/thesis-view.asp?key=1857522-
dc.subject.keyword종양-
dc.subject.keyword-
dc.subject.keyword자궁경부암-
dc.subject.keywordANNEXIN-Ⅰ-
dc.subject.keywordAnnexin-I-
dc.subject.keywordCervical cancer-
dc.subject.keywordProliferation-
dc.contributor.alternativeNameKim, Jae Hoon-
dc.contributor.affiliatedAuthor김재훈-
dc.citation.volume42-
dc.citation.number10-
dc.citation.startPage2199-
dc.citation.endPage2204-
dc.identifier.bibliographicCitationKorean Journal of Obstetrics and Gynecology (대한산부인과학회잡지), Vol.42(10) : 2199-2204, 1999-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

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