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자궁경부암 세포의 증식에 관여하는 annexin-Ⅰ의 역할
DC Field | Value | Language |
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dc.contributor.author | 김재훈 | - |
dc.date.accessioned | 2020-01-23T05:28:32Z | - |
dc.date.available | 2020-01-23T05:28:32Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0494-4755 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/174313 | - |
dc.description.abstract | Objectives: To investigate the role of annexin-I in human cervical cancer, we evaluated the expression of annexin-I and the relation with the proliferation of cancer cells. Methods: By immunohistochemical analysis and the western blotting of annexin-I , we investigated the extent and distribution of the expression of annexin-I in cervical cancer tissues. After treating the human cancer cell lines ( SiHa and HeLa cell lines ) with tamoxifen, estradiol, and retinoic acid for 5 days to make the cells proliferate and antiproliferate, we measured the proliferation simultaneously with 3-(4,5- dimethyl thiazol- 2-yl)-2,5-diphenyl-tetr -azolium bromide (MTT) colorimetric assay and the expression level of annexin-I with flowcytometry. Results: In the immunohistochemical stains, a granular staining pattern involving the entire cytoplasm was more heavily observed in malignant lesions than in normals. In the western blotting, the antibodies against 35-kDa annexin-I appeared to react more strongly with the lysates of cancer tissues than normal and benign tissues. In SiHa and HeLa cell lines with tamoxifen and β- estradiol treatment, increased expressions of annexin-I were noted with correlated increased proliferation of cells, and with the treatments of all trans retinoic acid, decreased expressions of annexin-I were noted with correlated decreased proliferation of cells. Conclusions: The results suggest that the expression of annexin-I might correlate with cervical cancer than normal and the proliferation of cancer cells. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | Korean | - |
dc.publisher | 대한산부인과학회 | - |
dc.relation.isPartOf | Korean Journal of Obstetrics and Gynecology (대한산부인과학회잡지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 자궁경부암 세포의 증식에 관여하는 annexin-Ⅰ의 역할 | - |
dc.title.alternative | Role of annexin-I in cervical cancer cell proliferation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics and Gynecology (산부인과학교실) | - |
dc.contributor.googleauthor | 유영옥 | - |
dc.contributor.googleauthor | 박태철 | - |
dc.contributor.googleauthor | 남궁성은 | - |
dc.contributor.googleauthor | 박동춘 | - |
dc.contributor.googleauthor | 김재훈 | - |
dc.contributor.googleauthor | 김대훈 | - |
dc.contributor.googleauthor | 양용재 | - |
dc.contributor.googleauthor | 이지현 | - |
dc.contributor.googleauthor | 조성대 | - |
dc.contributor.googleauthor | 조형권 | - |
dc.contributor.localId | A00876 | - |
dc.relation.journalcode | J02075 | - |
dc.identifier.url | http://kiss.kstudy.com/thesis/thesis-view.asp?key=1857522 | - |
dc.subject.keyword | 종양 | - |
dc.subject.keyword | 암 | - |
dc.subject.keyword | 자궁경부암 | - |
dc.subject.keyword | ANNEXIN-Ⅰ | - |
dc.subject.keyword | Annexin-I | - |
dc.subject.keyword | Cervical cancer | - |
dc.subject.keyword | Proliferation | - |
dc.contributor.alternativeName | Kim, Jae Hoon | - |
dc.contributor.affiliatedAuthor | 김재훈 | - |
dc.citation.volume | 42 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2199 | - |
dc.citation.endPage | 2204 | - |
dc.identifier.bibliographicCitation | Korean Journal of Obstetrics and Gynecology (대한산부인과학회잡지), Vol.42(10) : 2199-2204, 1999 | - |
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