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The prediction of interferon-α therapeutic effect by sequence variation of the HCV hypervariable region 1

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dc.contributor.author김현숙-
dc.date.accessioned2020-01-23T05:15:20Z-
dc.date.available2020-01-23T05:15:20Z-
dc.date.issued1999-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/174126-
dc.description.abstractInterferon-alpha (IFN-alpha) has been used to treat hepatitis C virus (HCV)-induced hepatitis, but it has been effective in only about half of the treated patients, with recurrence appearing in the other half. As a consequence of the possible complications associated with IFN-alpha and the high cost of treatment, it has become extremely important to select the proper patients for IFN-alpha treatment. In our previous study, we found that the quasispecies in the hypervariable region (HVR) 1 of HCV were various and that a new quasispecies can appear in non-responders and/or lead to deterioration in the patients' condition. The preliminary data we obtained in the process of our previous research led us to believe that the quasispecies of HVR 1 has something to do with the effect of IFN-alpha. Thus, in this investigation, we tried to determine the predictive factors of IFN-alpha therapy. Thirty patients with HCV infection were treated with IFN-alpha. Among them, 15 patients recovered after six months IFN-alpha treatment, but the remaining 15 patients showed no response after six months IFN-alpha treatment. We cloned HVR 1 DNA by reverse transcription-polymerase chain reaction (RT-PCR) and examined the quasispecies of HVR 1. As the quasispecies of HVR 1 in non-responders varied more than in the complete remission group, we concluded that the sequence variation in HVR 1 of HCV can be used to predict the effect of IFN-alpha.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYonsei Medical Journal-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAmino Acid Sequence-
dc.subject.MESHFemale-
dc.subject.MESHGenotype-
dc.subject.MESHHepacivirus/classification*-
dc.subject.MESHHepatitis C/drug therapy*-
dc.subject.MESHHepatitis C/virology-
dc.subject.MESHHumans-
dc.subject.MESHInterferon-alpha/therapeutic use*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMolecular Sequence Data-
dc.subject.MESHViral Nonstructural Proteins/blood-
dc.subject.MESHViral Nonstructural Proteins/chemistry*-
dc.subject.MESHViral Nonstructural Proteins/genetics-
dc.titleThe prediction of interferon-α therapeutic effect by sequence variation of the HCV hypervariable region 1-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학교실)-
dc.contributor.googleauthorByung Il Yeh-
dc.contributor.googleauthorHyun Won Kim-
dc.contributor.googleauthorHyon Suk Kim-
dc.contributor.googleauthorJong Young Lee-
dc.contributor.googleauthorKwang Ho Lee-
dc.contributor.googleauthorKang Mi Lee-
dc.contributor.googleauthorJin Suk Kim-
dc.contributor.googleauthorKwang Hyub Han-
dc.identifier.doi10.3349/ymj.1999.40.5.430-
dc.contributor.localIdA01117-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid10565252-
dc.contributor.alternativeNameKim, Hyon Suk-
dc.contributor.affiliatedAuthor김현숙-
dc.citation.volume40-
dc.citation.number5-
dc.citation.startPage430-
dc.citation.endPage438-
dc.identifier.bibliographicCitationYonsei Medical Journal, Vol.40(5) : 430-438, 1999-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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