Cited 2 times in
The prediction of interferon-α therapeutic effect by sequence variation of the HCV hypervariable region 1
DC Field | Value | Language |
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dc.contributor.author | 김현숙 | - |
dc.date.accessioned | 2020-01-23T05:15:20Z | - |
dc.date.available | 2020-01-23T05:15:20Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/174126 | - |
dc.description.abstract | Interferon-alpha (IFN-alpha) has been used to treat hepatitis C virus (HCV)-induced hepatitis, but it has been effective in only about half of the treated patients, with recurrence appearing in the other half. As a consequence of the possible complications associated with IFN-alpha and the high cost of treatment, it has become extremely important to select the proper patients for IFN-alpha treatment. In our previous study, we found that the quasispecies in the hypervariable region (HVR) 1 of HCV were various and that a new quasispecies can appear in non-responders and/or lead to deterioration in the patients' condition. The preliminary data we obtained in the process of our previous research led us to believe that the quasispecies of HVR 1 has something to do with the effect of IFN-alpha. Thus, in this investigation, we tried to determine the predictive factors of IFN-alpha therapy. Thirty patients with HCV infection were treated with IFN-alpha. Among them, 15 patients recovered after six months IFN-alpha treatment, but the remaining 15 patients showed no response after six months IFN-alpha treatment. We cloned HVR 1 DNA by reverse transcription-polymerase chain reaction (RT-PCR) and examined the quasispecies of HVR 1. As the quasispecies of HVR 1 in non-responders varied more than in the complete remission group, we concluded that the sequence variation in HVR 1 of HCV can be used to predict the effect of IFN-alpha. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | Yonsei Medical Journal | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Amino Acid Sequence | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Hepacivirus/classification* | - |
dc.subject.MESH | Hepatitis C/drug therapy* | - |
dc.subject.MESH | Hepatitis C/virology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interferon-alpha/therapeutic use* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Molecular Sequence Data | - |
dc.subject.MESH | Viral Nonstructural Proteins/blood | - |
dc.subject.MESH | Viral Nonstructural Proteins/chemistry* | - |
dc.subject.MESH | Viral Nonstructural Proteins/genetics | - |
dc.title | The prediction of interferon-α therapeutic effect by sequence variation of the HCV hypervariable region 1 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Byung Il Yeh | - |
dc.contributor.googleauthor | Hyun Won Kim | - |
dc.contributor.googleauthor | Hyon Suk Kim | - |
dc.contributor.googleauthor | Jong Young Lee | - |
dc.contributor.googleauthor | Kwang Ho Lee | - |
dc.contributor.googleauthor | Kang Mi Lee | - |
dc.contributor.googleauthor | Jin Suk Kim | - |
dc.contributor.googleauthor | Kwang Hyub Han | - |
dc.identifier.doi | 10.3349/ymj.1999.40.5.430 | - |
dc.contributor.localId | A01117 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 10565252 | - |
dc.contributor.alternativeName | Kim, Hyon Suk | - |
dc.contributor.affiliatedAuthor | 김현숙 | - |
dc.citation.volume | 40 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 430 | - |
dc.citation.endPage | 438 | - |
dc.identifier.bibliographicCitation | Yonsei Medical Journal, Vol.40(5) : 430-438, 1999 | - |
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