인간 자궁경부암조직에서 세포주기 조절단백 G1 Cyclins의 발현이 임상적 예후인자에 미치는 영향

Abstract

Alterations in the expression of genes that control the cell cycle may be of critical importance in tumorigenesis and malignant transformation. The major regulatory events leading to cell proliferation occur in G1 phase of cell cycle, and the deregulated expression of G1 cyclins is related to oncogenesis. Cyclins D1 and E play important roles in the progression of cell through G1 phase of the cell cycle. Amplification and/or overexpression of the cyclin D1 gene and aberrant expression of cyclin E has been described in various forms of human cancer. However, the role of cyclins D1 and E in cervical cancer has been poorly defined. In this study, we examined the expression of cyclins D1 and E by Northern blot technique and the status of human papillomavirus(HPV) type 16 and 18 by polymerase chain reaction in 25 cases of cervical carcinoma to explore the relationship between cyclins D1 and E and cervical cancer. We found cyclin D1 expression showed down-regulated expression in cervical cancer but cyclin E expression was increased in cancer group. Other clinicopathological prognostic factors were not correlated with cyclins D1 and E expression. Further study based on larger numbers of cases with correlation of cyclins D1 and E status and survival data will be needed to elucidate the use of cyclin expressions as prognostic factor.