Cited 11 times in
Regulation of type I collagen and interstitial collagenase mRNA expression in human dermal fibroblasts by colchicine and D-penicillamine
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정기양 | - |
dc.date.accessioned | 2020-01-23T05:04:37Z | - |
dc.date.available | 2020-01-23T05:04:37Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/173973 | - |
dc.description.abstract | Sclerosis is a disease process in which idiopathic hardening occurs in the skin and/or internal organs as a result of the accumulation of type I collagen, induced mainly by transforming growth factor-beta. Colchicine and D-penicillamine are widely used for its treatment. Their effects are known to be due to post-translational down-regulation of type I collagen synthesis, with colchicine also up-regulating interstitial collagenase. To determine whether or not they have any pre-translational effect on type I collagen and MMP-1, and also to observe their effects on the action of TGF-beta, cultured neonatal foreskin fibroblasts were treated with colchicine and D-penicillamine, singly and together. The amount of type I collagen and MMP-1 mRNA were quantitated by Northern blot hybridization. Colchicine suppresses the basal level of type I collagen mRNA but minimally stimulates the mRNA expression of MMP-1, whereas D-penicillamine does not have any significant effects on either. Colchicine was also able to significantly suppress the TGF-beta-induced up-regulation of type I collagen mRNA expression. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | Yonsei Medical Journal | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Colchicine/pharmacology* | - |
dc.subject.MESH | Collagen/genetics* | - |
dc.subject.MESH | Fibroblasts/metabolism | - |
dc.subject.MESH | Gene Expression Regulation/drug effects* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Matrix Metalloproteinase 1/genetics* | - |
dc.subject.MESH | Penicillamine/pharmacology* | - |
dc.subject.MESH | RNA, Messenger/analysis* | - |
dc.subject.MESH | Skin/cytology | - |
dc.subject.MESH | Skin/metabolism | - |
dc.subject.MESH | Transforming Growth Factor beta/pharmacology | - |
dc.title | Regulation of type I collagen and interstitial collagenase mRNA expression in human dermal fibroblasts by colchicine and D-penicillamine | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학교실) | - |
dc.contributor.googleauthor | Kee Yang Chung | - |
dc.contributor.googleauthor | Dong Seung Kang | - |
dc.identifier.doi | 10.3349/ymj.1999.40.5.490 | - |
dc.contributor.localId | A03582 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 10565262 | - |
dc.contributor.alternativeName | Chung, Kee Yang | - |
dc.contributor.affiliatedAuthor | 정기양 | - |
dc.citation.volume | 40 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 490 | - |
dc.citation.endPage | 495 | - |
dc.identifier.bibliographicCitation | Yonsei Medical Journal, Vol.40(5) : 490-495, 1999 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.