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FCA에 의한 염증 유발 후 주입된 L-NAME이 기계적 통각과민에 미치는 영향

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dc.contributor.author임중우-
dc.date.accessioned2020-01-10T02:07:20Z-
dc.date.available2020-01-10T02:07:20Z-
dc.date.issued1999-
dc.identifier.issn1226-2579-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/173888-
dc.description.abstractBackground: Effect of nitric oxide on the hyperalgesia induced by inflammation is controversial. From our previous experiment, NOS inhibitor, L-NAME given during the induction period decrease mechanical hyperalgesia occured by Freund's complete adjuvant induced inflammation. In addition, we attempted to analyze the effects of L-NAME on mechanical hyperalgesia after the development of inflammation by Freund's complete adjuvant in rat paw. Methods: Male Sprague Dawley rats were divided into four groups; control (normal saline), and three different doses of L-NAME (0.1 mg, 1 mg, 10 mg). Inflammation was induced in rats by injecting 0.15 ml of Freund's complete adjuvant (FCA) intraplantarly. Rats showed typical hyperalgesia within twelve hours after injection and maintained this for about one week. Tests were done 2 days after injection of FCA. After the baseline test either L-NAME or saline was injected under light halothane anesthesia. Effect of L-NAME on hyperalgesia was assessed by measuring mechanical hyperalgesia at 15, 30, 60, 90, 120 minutes. Same experients were repeated on normal rats. Results: When injected at the site of inflammation, L-NAME caused dose dependent decrease in mechanical hyperalgesia. However, normal rats also showed increased mechanical threshold after L- NAME injection. Conclusions: Although L-NAME reduces FCA induced mechanical hyperalgesia, this result may solely be due to inhibition of nitric oxide production and need to be further determined.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한통증학회-
dc.relation.isPartOfKorean Journal of Pain (대한통증학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleFCA에 의한 염증 유발 후 주입된 L-NAME이 기계적 통각과민에 미치는 영향-
dc.title.alternativeEffects of L-NAME on the Mechanical Hyperalgesia after the Development of Inflammation by Freund's Complete Adjuvant in Rat Paw-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Physiology (생리학교실)-
dc.contributor.googleauthor김민경-
dc.contributor.googleauthor최윤-
dc.contributor.googleauthor공현석-
dc.contributor.googleauthor임중우-
dc.contributor.googleauthor임항수-
dc.contributor.googleauthor정수진-
dc.contributor.googleauthor이청-
dc.contributor.localIdA03409-
dc.relation.journalcodeJ03702-
dc.contributor.alternativeNameLeem, Joong Woo-
dc.contributor.affiliatedAuthor임중우-
dc.citation.volume12-
dc.citation.number2-
dc.citation.startPage171-
dc.citation.endPage176-
dc.identifier.bibliographicCitationKorean Journal of Pain (대한통증학회지), Vol.12(2) : 171-176, 1999-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers

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