Cited 3 times in
Effects of retroviral-mediated herpes simplex virus thymidine kinase gene transfer to murine neuroblastoma cell lines in vitro and in vivo
DC Field | Value | Language |
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dc.contributor.author | 박영년 | - |
dc.contributor.author | 유철주 | - |
dc.date.accessioned | 2020-01-10T02:06:07Z | - |
dc.date.available | 2020-01-10T02:06:07Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0284-186X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/173873 | - |
dc.description.abstract | Selective introduction of genes conferring chemosensitivity on proliferating tumor cells can be used to treat cancer. We investigated the efficacy of retrovirus-mediated gene transfer of the herpes simplex virus thymidine kinase (HSV-TK) gene to murine neuroblastoma cell lines (neuro-2a) in vitro and in vivo. Retrovirus-mediated HSV-TK gene transfer to the neuro-2a cells resulted in sensitivity to ganciclovir (GCV) in vitro. In A/J mice, tumors produced from HSV-TK transduced neuro-2a cells regressed after GCV treatment. Intratumoral injection of recombinant retrovirus expressing HSV-TK gene also inhibited growth of the tumor established in A/J mice. These results demonstrate that HSV-TK gene therapy might be a feasible approach for inhibiting the growth of neuroblastoma. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Informa Healthcare | - |
dc.relation.isPartOf | Acta Oncologica | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Ganciclovir/therapeutic use | - |
dc.subject.MESH | Gene Expression | - |
dc.subject.MESH | Gene Transfer Techniques* | - |
dc.subject.MESH | Genetic Vectors* | - |
dc.subject.MESH | In Situ Nick-End Labeling | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred Strains | - |
dc.subject.MESH | Neuroblastoma/genetics | - |
dc.subject.MESH | Neuroblastoma/pathology | - |
dc.subject.MESH | Neuroblastoma/therapy* | - |
dc.subject.MESH | Retroviridae* | - |
dc.subject.MESH | Simplexvirus/enzymology | - |
dc.subject.MESH | Simplexvirus/genetics* | - |
dc.subject.MESH | Thymidine Kinase/genetics* | - |
dc.subject.MESH | Tumor Cells, Cultured/pathology | - |
dc.title | Effects of retroviral-mediated herpes simplex virus thymidine kinase gene transfer to murine neuroblastoma cell lines in vitro and in vivo | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Hyun-Sang Cho | - |
dc.contributor.googleauthor | Young Nyun Park | - |
dc.contributor.googleauthor | Chuhl-Joo Lyu | - |
dc.contributor.googleauthor | Chang Hyun Yang | - |
dc.contributor.googleauthor | Ki Yang Ryoo | - |
dc.contributor.googleauthor | Byung Soo Kim | - |
dc.contributor.googleauthor | Kir-Young Kim | - |
dc.contributor.googleauthor | Yeon-Soo Kim | - |
dc.identifier.doi | 10.1080/028418699432419 | - |
dc.contributor.localId | A01563 | - |
dc.contributor.localId | A02524 | - |
dc.relation.journalcode | J00024 | - |
dc.identifier.eissn | 1651-226X | - |
dc.identifier.pmid | 10665768 | - |
dc.identifier.url | https://www.tandfonline.com/doi/abs/10.1080/028418699432419 | - |
dc.contributor.alternativeName | Park, Young Nyun | - |
dc.contributor.affiliatedAuthor | 박영년 | - |
dc.contributor.affiliatedAuthor | 유철주 | - |
dc.citation.volume | 38 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1093 | - |
dc.citation.endPage | 1097 | - |
dc.identifier.bibliographicCitation | Acta Oncologica, Vol.38(8) : 1093-1097, 1999 | - |
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