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Effects of retroviral-mediated herpes simplex virus thymidine kinase gene transfer to murine neuroblastoma cell lines in vitro and in vivo

Authors
 Hyun-Sang Cho  ;  Young Nyun Park  ;  Chuhl-Joo Lyu  ;  Chang Hyun Yang  ;  Ki Yang Ryoo  ;  Byung Soo Kim  ;  Kir-Young Kim  ;  Yeon-Soo Kim 
Citation
 Acta Oncologica, Vol.38(8) : 1093-1097, 1999 
Journal Title
 Acta Oncologica 
ISSN
 0284-186X 
Issue Date
1999
MeSH
Animals ; Female ; Ganciclovir/therapeutic use ; Gene Expression ; Gene Transfer Techniques* ; Genetic Vectors* ; In Situ Nick-End Labeling ; Mice ; Mice, Inbred Strains ; Neuroblastoma/genetics ; Neuroblastoma/pathology ; Neuroblastoma/therapy* ; Retroviridae* ; Simplexvirus/enzymology ; Simplexvirus/genetics* ; Thymidine Kinase/genetics* ; Tumor Cells, Cultured/pathology
Abstract
Selective introduction of genes conferring chemosensitivity on proliferating tumor cells can be used to treat cancer. We investigated the efficacy of retrovirus-mediated gene transfer of the herpes simplex virus thymidine kinase (HSV-TK) gene to murine neuroblastoma cell lines (neuro-2a) in vitro and in vivo. Retrovirus-mediated HSV-TK gene transfer to the neuro-2a cells resulted in sensitivity to ganciclovir (GCV) in vitro. In A/J mice, tumors produced from HSV-TK transduced neuro-2a cells regressed after GCV treatment. Intratumoral injection of recombinant retrovirus expressing HSV-TK gene also inhibited growth of the tumor established in A/J mice. These results demonstrate that HSV-TK gene therapy might be a feasible approach for inhibiting the growth of neuroblastoma.
Full Text
https://www.tandfonline.com/doi/abs/10.1080/028418699432419
DOI
10.1080/028418699432419
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
Lyu, Chuhl Joo(유철주) ORCID logo https://orcid.org/0000-0001-7124-7818
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173873
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