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Association between apolipoprotein E polymorphism and macroalbuminuria in patients with non-insulin dependent diabetes mellitus

DC FieldValueLanguage
dc.contributor.author김정호-
dc.contributor.author한대석-
dc.date.accessioned2020-01-07T08:44:11Z-
dc.date.available2020-01-07T08:44:11Z-
dc.date.issued1999-
dc.identifier.issn0931-0509-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/173796-
dc.description.abstractOBJECTIVES: Apolipoprotein E (apo E) is known to play an important role in lipoprotein metabolism through its ability to bind to the receptors as a ligand. Three different apo E alleles (epsilon2, epsilon3 and epsilon4) produce six apo E genotypes (epsilon2/2, epsilon2/3, epsilon2/4, epsilon3/3, epsilon3/4 and epsilon4/4). The objective of this study was to investigate an association between apo E gene polymorphism and macroalbuminuria in 167 Korean patients with non-insulin dependent diabetes mellitus (NIDDM). METHODS: The patients in the macroalbuminuria group (n = 74) represent those in whom 24 h urinary albumin excretion was above 300 mg. The patients in the normoalbuminuria group (n = 93) represent those in whom 24 h urinary albumin excretion was below 30 mg and serum creatinine levels were less than 1.2 mg/dl. The duration of diabetes in all patients was at least 8 years. RESULTS: There were no significant differences in terms of age, sex, body mass index, HbA1c, total cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol between the two groups. In the macroalbuminuria group, the distribution of apo E genotypes revealed epsilon2/2 2 (2.7%), epsilon2/3 14 (18.9%), epsilon2/4 0 (0%), epsilon3/3 47 (63.5%), epsilon3/4 11 (14.9%) and epsilon4/4 0 (0%). In the normoalbuminuria group, the distribution of apo E genotypes revealed epsilon2/2 0 (0%), epsilon2/3 7 (7.5%), epsilon2/4 1 (1.1%), epsilon3/3 72 (77.4%), epsilon3/4 12 (12.9%) and epsilon4/4 1 (1.1%). There was no significant difference in the distribution of apo E genotypes between the two groups. However, there was a significant difference in the allele frequencies, epsilon2 frequency was significantly higher in macroalbuminuria group compared to normoalbuminuria group (12.2% vs 4.3%, P<0.05). Also, we compared apo E carrier frequencies between the two groups. Epsilon2 carrier frequency was significantly higher in macroalbuminuria group compared to normoalbuminuria group (21.6% vs 7.6%, P<0.05). In each group, there was no significant difference in the degree of lipid abnormalities between apo epsilon2 carrier (epsilon2/2, epsilon2/3 genotypes), epsilon3 carrier (epsilon3/3 genotype) and epsilon4 carrier (epsilon3/4, epsilon4/4 genotype). CONCLUSION: Apo epsilon2 allele and epsilon2 carrier frequencies were significantly higher in macroalbuminuria group. These results suggest that epsilon2 allele may be associated with the development of clinical albuminuria in Korean patients with NIDDM.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherOxford University Press-
dc.relation.isPartOfNephrol Dial Transplant-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAged-
dc.subject.MESHAlbuminuria/genetics*-
dc.subject.MESHAlleles-
dc.subject.MESHApolipoproteins E/blood-
dc.subject.MESHApolipoproteins E/genetics*-
dc.subject.MESHCarrier Proteins/blood-
dc.subject.MESHCarrier Proteins/genetics-
dc.subject.MESHDiabetes Mellitus, Type 2/blood*-
dc.subject.MESHDiabetes Mellitus, Type 2/genetics*-
dc.subject.MESHFemale-
dc.subject.MESHGene Frequency-
dc.subject.MESHGenotype-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPolymorphism, Genetic*-
dc.subject.MESHProtein Isoforms/blood-
dc.subject.MESHProtein Isoforms/genetics-
dc.subject.MESHReference Values-
dc.titleAssociation between apolipoprotein E polymorphism and macroalbuminuria in patients with non-insulin dependent diabetes mellitus-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학교실)-
dc.contributor.googleauthorSung-Kyu Ha-
dc.contributor.googleauthorHong Su Park-
dc.contributor.googleauthorKyung Wook Kim-
dc.contributor.googleauthorSeung Jung Kim-
dc.contributor.googleauthorDo-Hun Kim-
dc.contributor.googleauthorJung Ho Kim-
dc.contributor.googleauthorHo Yung Lee-
dc.contributor.googleauthorDae Suk Han-
dc.identifier.doi10.1093/ndt/14.9.2144-
dc.contributor.localIdA00903-
dc.contributor.localIdA04272-
dc.contributor.localIdA04272-
dc.relation.journalcodeJ02316-
dc.identifier.eissn1460-2385-
dc.identifier.pmid10489223-
dc.identifier.urlhttps://academic.oup.com/ndt/article/14/9/2144/1812325-
dc.contributor.alternativeNameKim, Jeong Ho-
dc.contributor.affiliatedAuthor김정호-
dc.contributor.affiliatedAuthor한대석-
dc.contributor.affiliatedAuthor한대석-
dc.citation.volume14-
dc.citation.number9-
dc.citation.startPage2144-
dc.citation.endPage2149-
dc.identifier.bibliographicCitationNephrol Dial Transplant, Vol.14(9) : 2144-2149, 1999-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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