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Excessive tau accumulation in the parieto-occipital cortex characterizes early-onset Alzheimer's disease

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dc.contributor.author조한나-
dc.date.accessioned2019-12-31T01:24:27Z-
dc.date.available2019-12-31T01:24:27Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/173623-
dc.description.abstractBackground: Early-onset Alzheimer’s disease (EOAD) is associated with a greater impairment of various non-memory functions, more rapid progression, and greater cortical hypometabolism and atrophy when compared to late-onset AD (LOAD) even when similar amyloid-β burden was present in positron emission tomography (PET) studies. We sought to investigate the differences in topographical patterns of tau accumulation between the early- and late-onset patients with AD and mild cognitive impairment (MCI). Methods: In 90 amnestic MCI and mild to moderate AD patients who completed 18F-AV-1451 and 18F-florbetaben positron emission tomography scans, 59 amyloid-positive patients were included (11 EOAD, 10 EOMCI, 21 LOAD, and 17 LOMCI). We compared cortical 18F-AV-1451 and 18F-florbetaben binding between each patient group and corresponding amyloid-negative age-matched controls. Results: Compared to each control group, both EOAD and LOAD groups showed markedly increased 18F-AV- 1451 binding across the entire neocortex, while only the LOMCI group showed increased binding in the medial temporal cortex. In contrast to no difference in cortical 18F-AV-1451 binding between the EOMCI and LOMCI, the EOAD showed greater 18F-AV-1451 binding in the parieto-occipital cortex than LOAD. The parieto-occipital 18F-AV-1451 binding correlated with the visuospatial dysfunction in EOAD spectrum, while the binding in the temporal cortex correlated with verbal memory dysfunction in LOAD spectrum. Cortical 18F-florbetaben binding did not differ between the EOAD and LOAD groups. Conclusion: EOAD patients have a greater tau burden, particularly in the parieto-occipital cortex than LOAD patients. Distinct topographic distribution of tau may influence the nature of cognitive impairment in EOAD patients.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.publisher연세대학교 대학원-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleExcessive tau accumulation in the parieto-occipital cortex characterizes early-onset Alzheimer's disease-
dc.title.alternative조기발현형 알츠하이머 병에서 나타나는 특징적인 두정-후두엽 피질의 과도한 타우 축적 양상-
dc.typeThesis-
dc.contributor.collegeGraduate School, Yonsei University-
dc.contributor.departmentDept. of Medicine-
dc.contributor.localIdA03920-
dc.description.degree박사-
dc.contributor.alternativeNameCho, Hanna-
dc.contributor.affiliatedAuthor조한나-
dc.type.localDissertation-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 3. Dissertation

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