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Therapeutic Outcome of Achalasia Based on High-Resolution Manometry: A Korean Multicenter Study
DC Field | Value | Language |
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dc.contributor.author | 박효진 | - |
dc.contributor.author | 윤영훈 | - |
dc.date.accessioned | 2019-12-18T01:27:19Z | - |
dc.date.available | 2019-12-18T01:27:19Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1075-2765 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/173528 | - |
dc.description.abstract | BACKGROUND: Because achalasia subtype is associated with therapeutic response, it is possible that regional differences in subtype distribution could lead to differences in therapeutic outcomes. STUDY QUESTION: We aimed to evaluate and compare high-resolution manometry (HRM) profiles among the different subtypes of achalasia and to elucidate predictive factors associated with treatment outcomes. STUDY DESIGN: Patients who were diagnosed with achalasia using HRM at 4 Korean university hospitals were retrospectively identified and analyzed. Sixty-four patients with untreated achalasia were divided into 3 subtypes using the Chicago classification system. MEASURES AND OUTCOMES: Clinical characteristics, manometric features, and treatment outcomes were compared. RESULTS: Among 64 patients diagnosed with achalasia, 31 patients were classified as type I, 27 as type II, and 6 as type III. Regarding HRM parameters, there were statistically significant differences in basal lower esophageal sphincter pressure, 4-second-integrated relaxation pressure, residual upper esophageal sphincter pressure, body amplitude, and maximal intrabolus pressure between subtypes. Regarding therapeutic outcome, type II patients (overall success rate of 80.0%) were more likely to respond than type I (55.2%) or type III (33.2%) patients. Multivariate analysis demonstrated that achalasia subtype (type I vs. III, P = 0.072; type II vs. III, P = 0.005), therapeutic modality (dilation vs. pharmacologic, P = 0.013; laparoscopic Heller's myotomy vs. pharmacologic, P = 0.006), and HRM-measured esophageal length (<27.5 vs. ≥27.5 cm, P = 0.014) are independent predictive factors for therapeutic failure. CONCLUSIONS: Patients with type II achalasia had better treatment outcomes than patients with other achalasia subtypes. Achalasia subtype, therapeutic modality, and esophageal length are independent predictive factors of therapeutic outcome. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF THERAPEUTICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Therapeutic Outcome of Achalasia Based on High-Resolution Manometry: A Korean Multicenter Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Lee, Hyuk | - |
dc.contributor.googleauthor | Chung, Hyunsoo | - |
dc.contributor.googleauthor | Lee, Tae Hee | - |
dc.contributor.googleauthor | Hong, Kyoung Sup | - |
dc.contributor.googleauthor | Youn, Young Hoon | - |
dc.contributor.googleauthor | Park, Jung Ho | - |
dc.contributor.googleauthor | Park, Hyung Seok | - |
dc.contributor.googleauthor | Park, Hyojin | - |
dc.identifier.doi | 10.1097/MJT.000000000000677 | - |
dc.contributor.localId | A01774 | - |
dc.contributor.localId | A02583 | - |
dc.relation.journalcode | J02842 | - |
dc.identifier.eissn | 1536-3686 | - |
dc.identifier.pmid | 28953511 | - |
dc.identifier.url | https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00045391-201908000-00003&LSLINK=80&D=ovft | - |
dc.contributor.alternativeName | Park, Hyo Jin | - |
dc.contributor.affiliatedAuthor | 박효진 | - |
dc.contributor.affiliatedAuthor | 윤영훈 | - |
dc.citation.volume | 26 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | e452 | - |
dc.citation.endPage | e461 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF THERAPEUTICS, Vol.26(4) : e452-e461, 2019 | - |
dc.identifier.rimsid | 64467 | - |
dc.type.rims | ART | - |
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