Cited 27 times in
Nonalcoholic fatty liver disease is an early predictor of metabolic diseases in a metabolically healthy population
DC Field | Value | Language |
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dc.contributor.author | 강신애 | - |
dc.date.accessioned | 2019-12-18T01:25:37Z | - |
dc.date.available | 2019-12-18T01:25:37Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/173511 | - |
dc.description.abstract | AIMS: The relationship between nonalcoholic fatty liver disease and incident metabolic syndrome in metabolically healthy subjects is unknown. We aimed to investigate whether nonalcoholic fatty liver disease is a predictor of future metabolic syndrome in metabolically healthy subjects. MATERIALS AND METHODS: Subjects who underwent health evaluation at least twice between 2009 and 2015 from the National Health Insurance Service-National Sample Cohort in South Korea were included. Patients without obesity who had no metabolic syndrome components were finally analyzed (n = 28,880). The definition of nonalcoholic fatty liver disease was based on both the hepatic steatosis and fatty liver indices. The incidence of metabolic syndrome, prediabetes/type 2 diabetes, hypertension, and dyslipidemia was compared between the subjects with and without nonalcoholic fatty liver disease. RESULTS: The presence of nonalcoholic fatty liver disease was associated with a higher risk of incident metabolic syndrome, prediabetes/type 2 diabetes, hypertension, and dyslipidemia in the entire cohort (metabolic syndrome: adjusted hazard ratio, 2.10; 95% confidence interval, 1.18-3.71; prediabetes/type 2 diabetes: adjusted hazard ratio, 1.42; 95% confidence interval, 1.06-1.90; hypertension: adjusted hazard ratio, 2.36; 95% confidence interval, 1.35-4.12; dyslipidemia: adjusted hazard ratio, 1.49; 95% confidence interval, 1.07-2.06). A similar finding was observed in the age-, sex-, smoking status-, and body mass index-based 1:5 propensity score-matched cohort of 1,092 subjects (metabolic syndrome: adjusted hazard ratio, 3.56; 95% confidence interval, 1.79-7.07; prediabetes/type 2 diabetes: adjusted hazard ratio, 1.97; 95% confidence interval, 1.04-3.73; hypertension: adjusted hazard ratio, 2.57; 95% confidence interval, 1.35-4.88; dyslipidemia: adjusted hazard ratio, 1.61; 95% confidence interval, 1.12-2.32). CONCLUSIONS: Nonalcoholic fatty liver disease is an early predictor of metabolic dysfunction even in metabolically healthy populations. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Nonalcoholic fatty liver disease is an early predictor of metabolic diseases in a metabolically healthy population | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Seokhun Yang | - |
dc.contributor.googleauthor | Soongu Kwak | - |
dc.contributor.googleauthor | Jeong-Hoon Lee | - |
dc.contributor.googleauthor | Shinae Kang | - |
dc.contributor.googleauthor | Seung-Pyo Lee | - |
dc.identifier.doi | 10.1371/journal.pone.0224626 | - |
dc.contributor.localId | A00052 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 31682638 | - |
dc.contributor.alternativeName | Kang, Shin Ae | - |
dc.contributor.affiliatedAuthor | 강신애 | - |
dc.citation.volume | 14 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | e0224626 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.14(11) : e0224626, 2019 | - |
dc.identifier.rimsid | 64382 | - |
dc.type.rims | ART | - |
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