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The Effectiveness of Intermittent Fasting to Reduce Body Mass Index and Glucose Metabolism: A Systematic Review and Meta-Analysis

DC FieldValueLanguage
dc.contributor.author강은석-
dc.contributor.author김경원-
dc.contributor.author이민영-
dc.contributor.author이병완-
dc.contributor.author이용호-
dc.contributor.author조성준-
dc.contributor.author차봉수-
dc.contributor.author홍남기-
dc.date.accessioned2019-12-18T01:25:19Z-
dc.date.available2019-12-18T01:25:19Z-
dc.date.issued2019-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/173510-
dc.description.abstractThe effects of an intermittent fasting diet (IFD) in the general population are still controversial. In this study, we aimed to systematically evaluate the effectiveness of an IFD to reduce body mass index and glucose metabolism in the general population without diabetes mellitus. Cochrane, PubMed, and Embase databases were searched to identify randomized controlled trials and controlled clinical trials that compared an IFD with a regular diet or a continuous calorie restriction diet. The effectiveness of an IFD was estimated by the weighted mean difference (WMD) for several variables associated with glucometabolic parameters including body mass index (BMI) and fasting glucose. The pooled mean differences of outcomes were calculated using a random effects model. From 2814 studies identified through a literature search, we finally selected 12 articles (545 participants). Compared with a control diet, an IFD was associated with a significant decline in BMI (WMD, -0.75 kg/m2; 95% CI, -1.44 to -0.06), fasting glucose level (WMD, -4.16 mg/dL; 95% CI, -6.92 to -1.40), and homeostatic model assessment of insulin resistance (WMD, -0.54; 95% CI, -1.05 to -0.03). Fat mass (WMD, -0.98 kg; 95% CI, -2.32 to 0.36) tended to decrease in the IFD group with a significant increase in adiponectin (WMD, 1008.9 ng/mL; 95% CI, 140.5 to 1877.3) and a decrease in leptin (WMD, -0.51 ng/mL; 95% CI, -0.77 to -0.24) levels. An IFD may provide a significant metabolic benefit by improving glycemic control, insulin resistance, and adipokine concentration with a reduction of BMI in adults.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI AG-
dc.relation.isPartOfJOURNAL OF CLINICAL MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleThe Effectiveness of Intermittent Fasting to Reduce Body Mass Index and Glucose Metabolism: A Systematic Review and Meta-Analysis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorYongin Cho-
dc.contributor.googleauthorNamki Hong-
dc.contributor.googleauthorKyung-won Kim-
dc.contributor.googleauthorSung joon Cho-
dc.contributor.googleauthorMinyoung Lee-
dc.contributor.googleauthorYeon-hee Lee-
dc.contributor.googleauthorYong-ho Lee-
dc.contributor.googleauthorEun Seok Kang-
dc.contributor.googleauthorBong-Soo Cha-
dc.contributor.googleauthorByung-Wan Lee-
dc.identifier.doi10.3390/jcm8101645-
dc.contributor.localIdA00068-
dc.contributor.localIdA05783-
dc.contributor.localIdA05783-
dc.contributor.localIdA05491-
dc.contributor.localIdA05491-
dc.contributor.localIdA02796-
dc.contributor.localIdA02796-
dc.contributor.localIdA02989-
dc.contributor.localIdA02989-
dc.contributor.localIdA05807-
dc.contributor.localIdA05807-
dc.contributor.localIdA03996-
dc.contributor.localIdA03996-
dc.contributor.localIdA04388-
dc.contributor.localIdA04388-
dc.relation.journalcodeJ03556-
dc.identifier.eissn2077-0383-
dc.identifier.pmid31601019-
dc.subject.keywordbody mass index-
dc.subject.keywordglucose metabolism-
dc.subject.keywordinsulin resistance-
dc.subject.keywordintermittent fasting-
dc.contributor.alternativeNameKang, Eun Seok-
dc.contributor.affiliatedAuthor강은석-
dc.contributor.affiliatedAuthor김경원-
dc.contributor.affiliatedAuthor김경원-
dc.contributor.affiliatedAuthor이민영-
dc.contributor.affiliatedAuthor이민영-
dc.contributor.affiliatedAuthor이병완-
dc.contributor.affiliatedAuthor이병완-
dc.contributor.affiliatedAuthor이용호-
dc.contributor.affiliatedAuthor이용호-
dc.contributor.affiliatedAuthor조성준-
dc.contributor.affiliatedAuthor조성준-
dc.contributor.affiliatedAuthor차봉수-
dc.contributor.affiliatedAuthor차봉수-
dc.contributor.affiliatedAuthor홍남기-
dc.contributor.affiliatedAuthor홍남기-
dc.citation.volume8-
dc.citation.number10-
dc.citation.startPageE1645-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL MEDICINE, Vol.8(10) : E1645, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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