Cited 10 times in
Rituximab protects against development of atherosclerotic cardiovascular disease after kidney transplantation: a propensity-matched study
DC Field | Value | Language |
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dc.contributor.author | 김덕기 | - |
dc.contributor.author | 김명수 | - |
dc.contributor.author | 김범석 | - |
dc.contributor.author | 김순일 | - |
dc.contributor.author | 김유선 | - |
dc.contributor.author | 이재근 | - |
dc.contributor.author | 이주한 | - |
dc.contributor.author | 허규하 | - |
dc.date.accessioned | 2019-12-18T01:24:11Z | - |
dc.date.available | 2019-12-18T01:24:11Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/173502 | - |
dc.description.abstract | Recent studies have implicated B cells in atherosclerosis and have verified the atheroprotective effect of rituximab. Rituximab is widely used for desensitization in ABO-incompatible or crossmatch-positive kidney transplantation (KT). Using a single-center KT database, we performed propensity-matched analysis to investigate the association between rituximab and posttransplant atherosclerotic cardiovascular disease (ASCVD). Among 1299 eligible patients, 239 given rituximab induction were matched with 401 controls in a 1:2 propensity score matching process. The cumulative rate of ASCVD during 8 years of follow-up was significantly lower in rituximab-treated patients, compared with matched controls (3.7% vs. 11.2%; P = 0.012). However, all-cause mortality did not differ by group (2.9% vs. 4%; P = 0.943). In multivariable Cox analysis, rituximab proved independently protective of ASCVD (hazard ratio = 0.34, 95% confidence interval: 0.14-0.83). The lower risk of ASCVD seen with rituximab induction reached significance only in patient subsets of diabetes mellitus, pretransplant dialysis, or older age (>50 years). Rituximab induction confers a lower risk of ASCVD during the posttransplant period. This atheroprotective effect appears particularly beneficial in patients whose risk of ASCVD is heightened. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Rituximab protects against development of atherosclerotic cardiovascular disease after kidney transplantation: a propensity-matched study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Deok Gie Kim | - |
dc.contributor.googleauthor | Juhan Lee | - |
dc.contributor.googleauthor | Won Jun Seo | - |
dc.contributor.googleauthor | Jae Geun Lee | - |
dc.contributor.googleauthor | Beom Seok Kim | - |
dc.contributor.googleauthor | Myoung Soo Kim | - |
dc.contributor.googleauthor | Soon Il Kim | - |
dc.contributor.googleauthor | Yu Seun Kim | - |
dc.contributor.googleauthor | Kyu Ha Huh | - |
dc.identifier.doi | 10.1038/s41598-019-52942-8 | - |
dc.contributor.localId | A05303 | - |
dc.contributor.localId | A00424 | - |
dc.contributor.localId | A00488 | - |
dc.contributor.localId | A00649 | - |
dc.contributor.localId | A00785 | - |
dc.contributor.localId | A03068 | - |
dc.contributor.localId | A03163 | - |
dc.contributor.localId | A04344 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 31712593 | - |
dc.contributor.alternativeName | Kim, Deok Gie | - |
dc.contributor.affiliatedAuthor | 김덕기 | - |
dc.contributor.affiliatedAuthor | 김명수 | - |
dc.contributor.affiliatedAuthor | 김범석 | - |
dc.contributor.affiliatedAuthor | 김순일 | - |
dc.contributor.affiliatedAuthor | 김유선 | - |
dc.contributor.affiliatedAuthor | 이재근 | - |
dc.contributor.affiliatedAuthor | 이주한 | - |
dc.contributor.affiliatedAuthor | 허규하 | - |
dc.citation.volume | 9 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | e16475 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.9(1) : e16475, 2019 | - |
dc.identifier.rimsid | 63545 | - |
dc.type.rims | ART | - |
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