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Human cytomegalovirus seroprevalence and titres in solid organ transplant recipients and transplant donors in Seoul, South Korea

DC FieldValueLanguage
dc.contributor.author송영구-
dc.contributor.author이경화-
dc.contributor.author한상훈-
dc.date.accessioned2019-12-18T01:17:32Z-
dc.date.available2019-12-18T01:17:32Z-
dc.date.issued2019-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/173457-
dc.description.abstractBACKGROUND: Human cytomegalovirus (HCMV) can cause poor outcomes in solid organ transplant (SOT) recipients; moreover, it is associated with cardiovascular diseases (CVD) in the general population. Accordingly, anti-HCMV immunoglobulin G (IgG) seroepidemiology may be useful in identifying the risk of post-SOT HCMV infection or disease as well as immunosenescence or CVD. However, HCMV seroprevalence and titre have not been fully evaluated with regard to age distribution or compared between SOT recipients and healthy individuals in South Korea. METHODS: We retrospectively retrieved all unduplicated anti-HCMV IgG results of individuals aged > 1 year evaluated between July 2006 and November 2017 at Severance Hospital in Seoul. The cohort, excluding haematopoietic stem cell transplant recipients and subjects with equivocal values, included 2184 SOT recipients and 3015 healthy transplant donors. All IgG results in the SOT recipients were measured during the pre-transplant period. RESULTS: The overall IgG seroprevalence and titres were significantly higher among SOT recipients than among healthy donors (98.7% vs. 88.6%, p < 0.001, and 64.7 ± 44.3 vs. 49.8 ± 20.6 arbitrary units/mL, p < 0.001, respectively). The lowest seropositive rate in the SOT group was observed in recipients aged between 11 and 15 years (70.6%). The frequency of seropositivity among adults aged ≥41 years increased to ≥90% in SOT recipients and healthy donors. Age was independently associated with higher HCMV seroprevalence (41-60 years, OR, 76.4, 95% CI, 24.5-238.9, p < 0.001; ≥ 61 years, OR, 4.4, 95% CI, 1.3-14.9, p < 0.001, compared to ≤40 years). The healthy donor group had an independently low HCMV seropositive rate (OR, 0.1, 95% CI, 0.1-0.2, p < 0.001). CONCLUSIONS: HCMV seropositivity was the lowest among school-aged children and adolescents. IgG testing revealed an intermediate serostatus risk of post-transplant HCMV infection and disease for most adult SOT recipients in South Korea.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBioMed Central-
dc.relation.isPartOfBMC INFECTIOUS DISEASES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleHuman cytomegalovirus seroprevalence and titres in solid organ transplant recipients and transplant donors in Seoul, South Korea-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorYeonju La-
dc.contributor.googleauthorDa Eun Kwon-
dc.contributor.googleauthorSeul Gi Yoo-
dc.contributor.googleauthorKyoung Hwa Lee-
dc.contributor.googleauthorSang Hoon Han-
dc.contributor.googleauthorYong Goo Song-
dc.identifier.doi10.1186/s12879-019-4607-x-
dc.contributor.localIdA02037-
dc.contributor.localIdA04620-
dc.contributor.localIdA04620-
dc.contributor.localIdA04286-
dc.contributor.localIdA04286-
dc.relation.journalcodeJ00360-
dc.identifier.eissn1471-2334-
dc.identifier.pmid31703564-
dc.subject.keywordAge-
dc.subject.keywordHuman cytomegalovirus-
dc.subject.keywordSeroprevalence-
dc.subject.keywordSolid organ transplantation-
dc.contributor.alternativeNameSong, Young Goo-
dc.contributor.affiliatedAuthor송영구-
dc.contributor.affiliatedAuthor이경화-
dc.contributor.affiliatedAuthor이경화-
dc.contributor.affiliatedAuthor한상훈-
dc.contributor.affiliatedAuthor한상훈-
dc.citation.volume19-
dc.citation.number1-
dc.citation.startPage948-
dc.identifier.bibliographicCitationBMC INFECTIOUS DISEASES, Vol.19(1) : 948, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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