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Peri-Coronary Adipose Tissue Density Is Associated With 18F-Sodium Fluoride Coronary Uptake in Stable Patients With High-Risk Plaques
DC Field | Value | Language |
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dc.contributor.author | 윤미진 | - |
dc.contributor.author | 장혁재 | - |
dc.contributor.author | 이상은 | - |
dc.date.accessioned | 2019-12-18T01:14:58Z | - |
dc.date.available | 2019-12-18T01:14:58Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1936-878X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/173438 | - |
dc.description.abstract | OBJECTIVES: This study aimed to assess the association between increased lesion peri-coronary adipose tissue (PCAT) density and coronary 18F-sodium fluoride (18F-NaF) uptake on positron emission tomography (PET) in stable patients with high-risk coronary plaques (HRPs) shown on coronary computed tomography angiography (CTA). BACKGROUND: Coronary 18F-NaF uptake reflects the rate of calcification of coronary atherosclerotic plaque. Increased PCAT density is associated with vascular inflammation. Currently, the relationship between increased PCAT density and 18F-NaF uptake in stable patients with HRPs on coronary CTA has not been characterized. METHODS: Patients who underwent coronary CTA were screened for HRP, which was defined by 3 concurrent plaque features: positive remodeling; low attenuation plaque (LAP) (<30 Hounsfield units [HU]) and spotty calcification; and obstructive coronary stenosis ≥50% (plaque volume >100 mm3). Patients with HRPs were recruited to undergo 18F-NaF PET/CT. In lesions with stenosis ≥25%, quantitative plaque analysis, mean PCAT density, maximal coronary motion-corrected 18F-NaF standard uptake values (SUVmax), and target-to-background ratios (TBR) were measured. RESULTS: Forty-one patients (age 65 ± 6 years; 68% men) were recruited. Fifty-one lesions in 23 patients (56%) showed increased coronary 18F-NaF activity. Lesions with 18F-NaF uptake had higher surrounding PCAT density than those without 18F-NaF uptake (-73 HU; interquartile range -79 to -68 HU vs. -86 HU; interquartile range -94 to -80 HU; p < 0.001). 18F-NaF TBR and SUVmax were correlated with PCAT density (r = 0.63 and r = 0.68, respectively; all p < 0.001). On adjusted multiple regression analysis, increased lesion PCAT density and LAP volume were associated with 18F-NaF TBR (β = 0.25; 95% confidence interval: 0.17 to 0.34; p < 0.001 for PCAT, and β = 0.07; 95% confidence interval: 0.03 to 0.11; p = 0.002 for LAP). CONCLUSIONS: In patients with HRP features on coronary CTA, increased density of PCAT was associated with focal 18F-NaF PET uptake. Simultaneous assessment of these imaging biomarkers by 18F-NaF PET and CTA might refine cardiovascular risk prediction in stable patients with HRP features. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | JACC-CARDIOVASCULAR IMAGING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Peri-Coronary Adipose Tissue Density Is Associated With 18F-Sodium Fluoride Coronary Uptake in Stable Patients With High-Risk Plaques | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Nuclear Medicine (핵의학교실) | - |
dc.contributor.googleauthor | Jacek Kwiecinski | - |
dc.contributor.googleauthor | Damini Dey | - |
dc.contributor.googleauthor | Sebastien Cadet | - |
dc.contributor.googleauthor | Sang-Eun Lee | - |
dc.contributor.googleauthor | Yuka Otaki | - |
dc.contributor.googleauthor | Phi T. Huynh | - |
dc.contributor.googleauthor | Mhairi K. Doris | - |
dc.contributor.googleauthor | Evann Eisenberg | - |
dc.contributor.googleauthor | Mijin Yun | - |
dc.contributor.googleauthor | Maurits A. Jansen | - |
dc.contributor.googleauthor | Michelle C. Williams | - |
dc.contributor.googleauthor | Balaji K. Tamarappoo | - |
dc.contributor.googleauthor | John D. Friedman | - |
dc.contributor.googleauthor | Marc R. Dweck | - |
dc.contributor.googleauthor | David E. Newby | - |
dc.contributor.googleauthor | Hyuk-Jae Chang | - |
dc.contributor.googleauthor | Piotr J. Slomka | - |
dc.contributor.googleauthor | Daniel S. Berman | - |
dc.identifier.doi | 10.1016/j.jcmg.2018.11.032 | - |
dc.contributor.localId | A02550 | - |
dc.contributor.localId | A03490 | - |
dc.relation.journalcode | J01192 | - |
dc.identifier.eissn | 1876-7591 | - |
dc.identifier.pmid | 30772226 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1936878X19300762 | - |
dc.subject.keyword | (18)F-sodium fluoride | - |
dc.subject.keyword | PET/CT | - |
dc.subject.keyword | coronary computed tomography angiography | - |
dc.subject.keyword | coronary imaging | - |
dc.subject.keyword | high-risk plaque | - |
dc.subject.keyword | peri-coronary adipose tissue density | - |
dc.contributor.alternativeName | Yun, Mi Jin | - |
dc.contributor.affiliatedAuthor | 윤미진 | - |
dc.contributor.affiliatedAuthor | 장혁재 | - |
dc.citation.volume | 12 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2000 | - |
dc.citation.endPage | 2010 | - |
dc.identifier.bibliographicCitation | JACC-CARDIOVASCULAR IMAGING, Vol.12(10) : 2000-2010, 2019 | - |
dc.identifier.rimsid | 63196 | - |
dc.type.rims | ART | - |
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