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Insights into the role of endoplasmic reticulum stress in skin function and associated diseases

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dc.contributor.author이상은-
dc.date.accessioned2019-12-18T01:05:25Z-
dc.date.available2019-12-18T01:05:25Z-
dc.date.issued2019-
dc.identifier.issn1742-464X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/173358-
dc.description.abstractEndoplasmic reticulum (ER) stress is a mechanism that allows the protection of normal cellular functions in response to both internal perturbations, such as accumulation of unfolded proteins, and external perturbations, for example redox stress, UVB irradiation, and infection. A hallmark of ER stress is the accumulation of misfolded and unfolded proteins. Physiological levels of ER stress trigger the unfolded protein response (UPR) that is required to restore normal ER functions. However, the UPR can also initiate a cell death program/apoptosis pathway in response to excessive or persistent ER stress. Recently, it has become evident that chronic ER stress occurs in several diseases, including skin diseases such as Darier's disease, rosacea, vitiligo and melanoma; furthermore, it is suggested that ER stress is directly involved in the pathogenesis of these disorders. Here, we review the role of ER stress in skin function, and discuss its significance in skin diseases.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherBlackwell Pub-
dc.relation.isPartOfFEBS Journal-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnimals-
dc.subject.MESHEndoplasmic Reticulum/metabolism-
dc.subject.MESHEndoplasmic Reticulum/pathology*-
dc.subject.MESHEndoplasmic Reticulum Stress*-
dc.subject.MESHHumans-
dc.subject.MESHProtein Folding-
dc.subject.MESHSignal Transduction-
dc.subject.MESHSkin/metabolism*-
dc.subject.MESHSkin Diseases/physiopathology*-
dc.subject.MESHUnfolded Protein Response*-
dc.titleInsights into the role of endoplasmic reticulum stress in skin function and associated diseases-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학교실)-
dc.contributor.googleauthorKyungho Park-
dc.contributor.googleauthorSang Eun Lee-
dc.contributor.googleauthorKyong‐Oh Shin-
dc.contributor.googleauthorYoshikazu Uchida-
dc.identifier.doi10.1111/febs.14739-
dc.contributor.localIdA02826-
dc.relation.journalcodeJ03718-
dc.identifier.eissn1742-4658-
dc.identifier.pmid30586218-
dc.identifier.urlhttps://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.14739-
dc.subject.keywordendoplasmic reticulum stress-
dc.subject.keywordskin disease-
dc.subject.keywordskin function-
dc.subject.keywordunfolded protein response-
dc.contributor.alternativeNameLee, Sang Eun-
dc.contributor.affiliatedAuthor이상은-
dc.citation.volume286-
dc.citation.number2-
dc.citation.startPage413-
dc.citation.endPage425-
dc.identifier.bibliographicCitationFEBS Journal, Vol.286(2) : 413-425, 2019-
dc.identifier.rimsid64366-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers

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