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Alpha-1 Adrenergic Receptor Blockers for the Treatment of Lower Urinary Tract Symptoms in Women: A Systematic Review and Meta-Analysis

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dc.contributor.author이주용-
dc.contributor.author조강수-
dc.contributor.author홍창희-
dc.date.accessioned2019-12-18T01:04:00Z-
dc.date.available2019-12-18T01:04:00Z-
dc.date.issued2019-
dc.identifier.issn2093-4777-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/173349-
dc.description.abstractPURPOSE: To assess the effectiveness of alpha-1 adrenergic receptor blockers (α1-blockers) in the treatment of female lower urinary tract symptoms (LUTS). METHODS: A literature search was conducted using the PubMed/MEDLINE, Embase, and Cochrane Library databases. Fourteen studies with 1,319 patients were ultimately included. The study comprised 2 analyses: a comparison of urinary symptom scores, maximal flow rate (Qmax), and postvoid residual (PVR) urine volume before and after α1-blocker administration in 8 prospective, open-label studies and 5 randomized clinical trials (RCTs); and an evaluation of the same variables in α1-blocker and placebo groups in 4 RCTs. RESULTS: The first meta-analysis showed that, following treatment, patients exhibited statistically significant symptom relief (mean difference [MD], -5.85; 95% confidence interval [CI], -7.71 to -3.99; P<0.00001), increased Qmax (MD, 3.67 mL/sec; 95% CI, 2.76-4.59 mL/sec; P<0.00001), and decreased PVR volume (MD, -28.46 mL; 95% CI, -34.99 to -21.93 mL; P<0.00001). In the second meta-analysis, α1-blockers demonstrated significant symptom relief relative to placebo (MD, -1.60; 95% CI, -2.68 to -0.51; P=0.004). However, no significant differences were observed in Qmax (MD, 0.05 mL/sec; 95% CI, -0.74 to 0.83 mL/sec, P=0.91) and PVR (MD, -8.10 mL; 95% CI, -32.32 to 16.12 mL, P=0.51) between the α1-blocker and placebo groups. CONCLUSION: These analyses suggest that α1-blockers are effective in the treatment of female LUTS patients. However, the effect of α1-blockers on female LUTS should be assessed according to the underlying cause, and the role of α1-blockers in combination therapy with other drugs should also be investigated.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한배뇨장애 및 요실금학회-
dc.relation.isPartOfINTERNATIONAL NEUROUROLOGY JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleAlpha-1 Adrenergic Receptor Blockers for the Treatment of Lower Urinary Tract Symptoms in Women: A Systematic Review and Meta-Analysis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Urology (비뇨의학교실)-
dc.contributor.googleauthorDo Kyung Kim-
dc.contributor.googleauthorJoo Yong Lee-
dc.contributor.googleauthorJae Hung Jung-
dc.contributor.googleauthorJae Heon Kim-
dc.contributor.googleauthorYoon Soo Hah-
dc.contributor.googleauthorChang Hee Hong-
dc.contributor.googleauthorKang Su Cho-
dc.identifier.doi10.5213/inj.1836188.094-
dc.contributor.localIdA03161-
dc.contributor.localIdA03801-
dc.contributor.localIdA04447-
dc.relation.journalcodeJ01817-
dc.identifier.pmid30943695-
dc.subject.keywordAlpha-adrenergic antagonists-
dc.subject.keywordLower urinary tract symptoms-
dc.subject.keywordMeta-analysis-
dc.subject.keywordVoiding dysfunction-
dc.subject.keywordWomen-
dc.contributor.alternativeNameLee, Joo Yong-
dc.contributor.affiliatedAuthor이주용-
dc.contributor.affiliatedAuthor조강수-
dc.contributor.affiliatedAuthor홍창희-
dc.citation.volume23-
dc.citation.number1-
dc.citation.startPage56-
dc.citation.endPage68-
dc.identifier.bibliographicCitationINTERNATIONAL NEUROUROLOGY JOURNAL, Vol.23(1) : 56-68, 2019-
dc.identifier.rimsid64276-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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