Cited 14 times in
Factors Associated With Psychosocial Functioning and Outcome of Individuals With Recent-Onset Schizophrenia and at Ultra-High Risk for Psychosis
DC Field | Value | Language |
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dc.contributor.author | 강지인 | - |
dc.contributor.author | 김경란 | - |
dc.contributor.author | 박진영 | - |
dc.contributor.author | 박혜윤 | - |
dc.contributor.author | 서은총 | - |
dc.contributor.author | 안석균 | - |
dc.contributor.author | 이은 | - |
dc.contributor.author | 이수영 | - |
dc.contributor.author | 김현규 | - |
dc.date.accessioned | 2019-12-18T01:03:41Z | - |
dc.date.available | 2019-12-18T01:03:41Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/173347 | - |
dc.description.abstract | Background: Patients with schizophrenia have impairments in social functioning and are readmitted to healthcare institutions frequently. Individuals at ultra-high risk (UHR) for psychosis already present poor social functioning; among those individuals, the conversion rate from the putative prodromal phase to overt psychosis is 20%-30% within 1-2 years. Here, we analyzed the factor structure of self-related variables and neuro- and socio-cognitive function, and investigated whether these factors were associated with psychosocial function and prognostic outcome in individuals with recent-onset schizophrenia (ROSPR) or at UHR for psychosis. Methods: We evaluated 60 individuals at UHR for psychosis, 47 individuals with ROSPR, and 71 healthy controls using a comprehensive neurocognitive test battery and self-reported attribution scales, self-esteem, resilience, aberrant subjective experiences of schizotypy (physical anhedonia, social anhedonia, magical ideation, and perceptual aberration), and basic symptoms. We assessed psychosocial function with the Quality of Life Scale (QLS). Results: Factor analysis of all subjects revealed a four-factor structure comprising social-cognitive bias, reflective self, neurocognition, and pre-reflective self factors. Multiple regression analysis at baseline revealed that the factor structure predicted QLS. In the UHR group, social-cognitive bias, reflective self, neurocognition, and negative symptoms were significant determinants, explaining 38.0% of total QLS score variance. In the ROSPR group, reflective self and negative symptoms were significant determinants, explaining 54.4% of total QLS score variance. During follow-up, 13 individuals at UHR for psychosis developed psychosis (cumulative prevalence: 31.2% ± 7.6% at 6 years), with neurocognition score at baseline remaining a significant predictor of conversion [χ2(1) = 4.009, p = 0.045; hazard ratio 0.56, 95% confidence interval 0.31-0.99, p = 0.048]. Five patients with schizophrenia were (re)admitted during follow-up (cumulative prevalence: 16.1% ± 7.1% at 6 years); no factor was found to predict (re)admission. Conclusion: Factor analysis revealed an intrinsic four-factor structure of social-cognitive bias, reflective self, neurocognition, and pre-reflective self. The four factors were associated with social functioning at baseline and prodrome-to-psychosis conversion during follow-up, indicating the clinical significance of the four-factor structure. These findings provide a framework for understanding schizophrenia. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Frontiers Research Foundation | - |
dc.relation.isPartOf | FRONTIERS IN PSYCHIATRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Factors Associated With Psychosocial Functioning and Outcome of Individuals With Recent-Onset Schizophrenia and at Ultra-High Risk for Psychosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학교실) | - |
dc.contributor.googleauthor | Hyun Kyu Kim | - |
dc.contributor.googleauthor | Hye Yoon Park | - |
dc.contributor.googleauthor | Eunchong Seo | - |
dc.contributor.googleauthor | Minji Bang | - |
dc.contributor.googleauthor | Yun Young Song | - |
dc.contributor.googleauthor | Su Young Lee | - |
dc.contributor.googleauthor | Kyung Ran Kim | - |
dc.contributor.googleauthor | Jin Young Park | - |
dc.contributor.googleauthor | Jee In Kang | - |
dc.contributor.googleauthor | Eun Lee | - |
dc.contributor.googleauthor | Suk Kyoon An | - |
dc.identifier.doi | 10.3389/fpsyt.2019.00459 | - |
dc.contributor.localId | A00084 | - |
dc.contributor.localId | A00293 | - |
dc.contributor.localId | A01701 | - |
dc.contributor.localId | A05542 | - |
dc.contributor.localId | A05571 | - |
dc.contributor.localId | A02227 | - |
dc.contributor.localId | A03032 | - |
dc.relation.journalcode | J03491 | - |
dc.identifier.eissn | 1664-0640 | - |
dc.identifier.pmid | 31293463 | - |
dc.subject.keyword | conversion | - |
dc.subject.keyword | psychosocial function | - |
dc.subject.keyword | readmission | - |
dc.subject.keyword | schizophrenia | - |
dc.subject.keyword | ultra-high risk for psychosis | - |
dc.contributor.alternativeName | Kang, Jee In | - |
dc.contributor.affiliatedAuthor | 강지인 | - |
dc.contributor.affiliatedAuthor | 김경란 | - |
dc.contributor.affiliatedAuthor | 박진영 | - |
dc.contributor.affiliatedAuthor | 박혜윤 | - |
dc.contributor.affiliatedAuthor | 서은총 | - |
dc.contributor.affiliatedAuthor | 안석균 | - |
dc.contributor.affiliatedAuthor | 이은 | - |
dc.citation.volume | 10 | - |
dc.citation.startPage | 459 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN PSYCHIATRY, Vol.10 : 459, 2019 | - |
dc.identifier.rimsid | 63317 | - |
dc.type.rims | ART | - |
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