84 158

Cited 2 times in

Factors Associated With Psychosocial Functioning and Outcome of Individuals With Recent-Onset Schizophrenia and at Ultra-High Risk for Psychosis

DC FieldValueLanguage
dc.contributor.author강지인-
dc.contributor.author김경란-
dc.contributor.author박진영-
dc.contributor.author박혜윤-
dc.contributor.author서은총-
dc.contributor.author안석균-
dc.contributor.author이은-
dc.contributor.author이수영-
dc.contributor.author김현규-
dc.date.accessioned2019-12-18T01:03:41Z-
dc.date.available2019-12-18T01:03:41Z-
dc.date.issued2019-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/173347-
dc.description.abstractBackground: Patients with schizophrenia have impairments in social functioning and are readmitted to healthcare institutions frequently. Individuals at ultra-high risk (UHR) for psychosis already present poor social functioning; among those individuals, the conversion rate from the putative prodromal phase to overt psychosis is 20%-30% within 1-2 years. Here, we analyzed the factor structure of self-related variables and neuro- and socio-cognitive function, and investigated whether these factors were associated with psychosocial function and prognostic outcome in individuals with recent-onset schizophrenia (ROSPR) or at UHR for psychosis. Methods: We evaluated 60 individuals at UHR for psychosis, 47 individuals with ROSPR, and 71 healthy controls using a comprehensive neurocognitive test battery and self-reported attribution scales, self-esteem, resilience, aberrant subjective experiences of schizotypy (physical anhedonia, social anhedonia, magical ideation, and perceptual aberration), and basic symptoms. We assessed psychosocial function with the Quality of Life Scale (QLS). Results: Factor analysis of all subjects revealed a four-factor structure comprising social-cognitive bias, reflective self, neurocognition, and pre-reflective self factors. Multiple regression analysis at baseline revealed that the factor structure predicted QLS. In the UHR group, social-cognitive bias, reflective self, neurocognition, and negative symptoms were significant determinants, explaining 38.0% of total QLS score variance. In the ROSPR group, reflective self and negative symptoms were significant determinants, explaining 54.4% of total QLS score variance. During follow-up, 13 individuals at UHR for psychosis developed psychosis (cumulative prevalence: 31.2% ± 7.6% at 6 years), with neurocognition score at baseline remaining a significant predictor of conversion [χ2(1) = 4.009, p = 0.045; hazard ratio 0.56, 95% confidence interval 0.31-0.99, p = 0.048]. Five patients with schizophrenia were (re)admitted during follow-up (cumulative prevalence: 16.1% ± 7.1% at 6 years); no factor was found to predict (re)admission. Conclusion: Factor analysis revealed an intrinsic four-factor structure of social-cognitive bias, reflective self, neurocognition, and pre-reflective self. The four factors were associated with social functioning at baseline and prodrome-to-psychosis conversion during follow-up, indicating the clinical significance of the four-factor structure. These findings provide a framework for understanding schizophrenia.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherFrontiers Research Foundation-
dc.relation.isPartOfFRONTIERS IN PSYCHIATRY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleFactors Associated With Psychosocial Functioning and Outcome of Individuals With Recent-Onset Schizophrenia and at Ultra-High Risk for Psychosis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Psychiatry (정신과학교실)-
dc.contributor.googleauthorHyun Kyu Kim-
dc.contributor.googleauthorHye Yoon Park-
dc.contributor.googleauthorEunchong Seo-
dc.contributor.googleauthorMinji Bang-
dc.contributor.googleauthorYun Young Song-
dc.contributor.googleauthorSu Young Lee-
dc.contributor.googleauthorKyung Ran Kim-
dc.contributor.googleauthorJin Young Park-
dc.contributor.googleauthorJee In Kang-
dc.contributor.googleauthorEun Lee-
dc.contributor.googleauthorSuk Kyoon An-
dc.identifier.doi10.3389/fpsyt.2019.00459-
dc.contributor.localIdA00084-
dc.contributor.localIdA00293-
dc.contributor.localIdA00293-
dc.contributor.localIdA01701-
dc.contributor.localIdA01701-
dc.contributor.localIdA05542-
dc.contributor.localIdA05542-
dc.contributor.localIdA05571-
dc.contributor.localIdA05571-
dc.contributor.localIdA02227-
dc.contributor.localIdA02227-
dc.contributor.localIdA03032-
dc.contributor.localIdA03032-
dc.relation.journalcodeJ03491-
dc.identifier.eissn1664-0640-
dc.identifier.pmid31293463-
dc.subject.keywordconversion-
dc.subject.keywordpsychosocial function-
dc.subject.keywordreadmission-
dc.subject.keywordschizophrenia-
dc.subject.keywordultra-high risk for psychosis-
dc.contributor.alternativeNameKang, Jee In-
dc.contributor.affiliatedAuthor강지인-
dc.contributor.affiliatedAuthor김경란-
dc.contributor.affiliatedAuthor김경란-
dc.contributor.affiliatedAuthor박진영-
dc.contributor.affiliatedAuthor박진영-
dc.contributor.affiliatedAuthor박혜윤-
dc.contributor.affiliatedAuthor박혜윤-
dc.contributor.affiliatedAuthor서은총-
dc.contributor.affiliatedAuthor서은총-
dc.contributor.affiliatedAuthor안석균-
dc.contributor.affiliatedAuthor안석균-
dc.contributor.affiliatedAuthor이은-
dc.contributor.affiliatedAuthor이은-
dc.citation.volume10-
dc.citation.startPage459-
dc.identifier.bibliographicCitationFRONTIERS IN PSYCHIATRY, Vol.10 : 459, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.