Cited 19 times in
Treatment Outcome after Fractionated Conformal Radiotherapy for Hepatocellular Carcinoma in Patients with Child-Pugh Classification B in Korea (KROG 16-05)
DC Field | Value | Language |
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dc.contributor.author | 김준원 | - |
dc.contributor.author | 성진실 | - |
dc.contributor.author | 이익재 | - |
dc.date.accessioned | 2019-12-18T01:01:50Z | - |
dc.date.available | 2019-12-18T01:01:50Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/173329 | - |
dc.description.abstract | PURPOSE: There is limited data on radiotherapy (RT) for hepatocellular carcinoma (HCC) in patients with Child-Pugh classification B (CP-B). This study aimed to evaluate the treatment outcomes of fractionated conformal RT in HCC patients with CP-B. Materials and Methods: We retrospectively reviewed the data of HCC patients with CP-B treated with RT between 2009 and 2014 at 13 institutions in Korea. HCC was diagnosed by the Korea guideline of 2009, and modern RT techniques were applied. Fraction size was ≤ 5 Gy and the biologically effective dose (BED) ≥ 40 Gy10 (α/β = 10 Gy). A total of 184 patients were included in this study. RESULTS: Initial CP score was seven in 62.0% of patients, eight in 31.0%, and nine in 7.0%. Portal vein tumor thrombosis was present in 66.3% of patients. The BED ranged from 40.4 to 89.6 Gy10 (median, 56.0 Gy10). After RT completion, 48.4% of patients underwent additional treatment. The median overall survival (OS) was 9.4 months. The local progression-free survival and OS rates at 1 year were 58.9% and 39.8%, respectively. In the multivariate analysis, non-classic radiation-induced liver disease (RILD) (p < 0.001) and additional treatment (p < 0.001) were the most significant prognostic factors of OS. Among 132 evaluable patients without progressive disease, 19.7% experienced non-classic RILD. Normal liver volume was the most predictive dosimetric parameter of non-classic RILD. CONCLUSION: Fractionated conformal RT showed favorable OS with a moderate risk non-classic RILD. The individual radiotherapy for CP-B could be cautiously applied weighing the survival benefits and the RILD risks. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English, Korean | - |
dc.publisher | Official journal of Korean Cancer Association | - |
dc.relation.isPartOf | CANCER RESEARCH AND TREATMENT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Treatment Outcome after Fractionated Conformal Radiotherapy for Hepatocellular Carcinoma in Patients with Child-Pugh Classification B in Korea (KROG 16-05) | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학교실) | - |
dc.contributor.googleauthor | Sun Hyun Bae | - |
dc.contributor.googleauthor | Hee Chul Park | - |
dc.contributor.googleauthor | Won Sup Yoon | - |
dc.contributor.googleauthor | Sang Min Yoon | - |
dc.contributor.googleauthor | In-Hye Jung | - |
dc.contributor.googleauthor | Ik Jae Lee | - |
dc.contributor.googleauthor | Jun Won Kim | - |
dc.contributor.googleauthor | Jinsil Seong | - |
dc.contributor.googleauthor | Tae Hyun Kim | - |
dc.contributor.googleauthor | Taek-Keun Nam | - |
dc.contributor.googleauthor | Youngmin Choi | - |
dc.contributor.googleauthor | Sun Young Lee | - |
dc.contributor.googleauthor | Hong Seok Jang | - |
dc.contributor.googleauthor | Dong Soo Lee | - |
dc.contributor.googleauthor | Jin Hee Kim | - |
dc.identifier.doi | 10.4143/crt.2018.687 | - |
dc.contributor.localId | A00958 | - |
dc.contributor.localId | A01956 | - |
dc.contributor.localId | A03055 | - |
dc.relation.journalcode | J00453 | - |
dc.identifier.eissn | 2005-9256 | - |
dc.identifier.pmid | 30971065 | - |
dc.subject.keyword | Child-Pugh B | - |
dc.subject.keyword | Hepatic toxicity | - |
dc.subject.keyword | Hepatocellular carcinoma | - |
dc.subject.keyword | Radiotherapy | - |
dc.contributor.alternativeName | Kim, Jun Won | - |
dc.contributor.affiliatedAuthor | 김준원 | - |
dc.contributor.affiliatedAuthor | 성진실 | - |
dc.contributor.affiliatedAuthor | 이익재 | - |
dc.citation.volume | 51 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1589 | - |
dc.citation.endPage | 1599 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, Vol.51(4) : 1589-1599, 2019 | - |
dc.identifier.rimsid | 63192 | - |
dc.type.rims | ART | - |
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