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THK5351 and flortaucipir PET with pathological correlation in a Creutzfeldt-Jakob disease patient: a case report

DC FieldValueLanguage
dc.contributor.author류철형-
dc.contributor.author유영훈-
dc.contributor.author조한나-
dc.date.accessioned2019-12-18T00:58:32Z-
dc.date.available2019-12-18T00:58:32Z-
dc.date.issued2019-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/173303-
dc.description.abstractBACKGROUND: THK5351 and flortaucipir tau ligands have high affinity for paired helical filament tau, yet diverse off-target bindings have been reported. Recent data support the hypothesis that THK5351 binds to monoamine oxidase B (MAO-B) expressed from reactive astrocytes and that flortaucipir has an affinity toward MAO-A and B; however, pathological evidence is lacking. We performed a head-to-head comparison of the two tau ligands in a sporadic Creutzfeldt-Jakob disease (CJD) patient and performed an imaging-pathological correlation study. CASE PRESENTATION: A 67-year-old man visited our clinic a history of 6 months of rapidly progressive dementia, visual disturbance, and akinetic mutism. Diffusion-weighted imaging showed cortical diffusion restrictions in the left temporo-parieto-occipital regions. 18F-THK5351 PET, but not 18F-flortaucipir PET showed high uptake in the left temporo-parieto-occipital regions, largely overlapping with the diffusion restricted areas. Cerebrospinal fluid analysis was weakly positive for 14-3-3 protein and pathogenic prion protein was found. The patient showed rapid cognitive decline along with myoclonic seizures and died 13 months after his first visit. A post-mortem study revealed immunoreactivity for PrPsc, no evidence of neurofibrillary tangles, and abundant astrocytosis which was reactive for MAO-B antibody. CONCLUSIONS: Our findings add pathological evidence that increased THK5351 uptake in sporadic CJD patients might be caused by an off-target binding driven by its high affinity for MAO-B.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherBioMed Central-
dc.relation.isPartOfBMC NEUROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAged-
dc.subject.MESHAminopyridines/pharmacology*-
dc.subject.MESHAutopsy-
dc.subject.MESHBrain/diagnostic imaging-
dc.subject.MESHBrain/pathology-
dc.subject.MESHCarbolines/pharmacology*-
dc.subject.MESHCreutzfeldt-Jakob Syndrome/diagnostic imaging*-
dc.subject.MESHCreutzfeldt-Jakob Syndrome/pathology*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMonoamine Oxidase/metabolism-
dc.subject.MESHNeurofibrillary Tangles/pathology-
dc.subject.MESHPositron-Emission Tomography/methods*-
dc.subject.MESHQuinolines/pharmacology*-
dc.subject.MESHtau Proteins/metabolism-
dc.titleTHK5351 and flortaucipir PET with pathological correlation in a Creutzfeldt-Jakob disease patient: a case report-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorHee Jin Kim-
dc.contributor.googleauthorHanna Cho-
dc.contributor.googleauthorSeongbeom Park-
dc.contributor.googleauthorHyemin Jang-
dc.contributor.googleauthorYoung Hoon Ryu-
dc.contributor.googleauthorJae Yong Choi-
dc.contributor.googleauthorSeung Hwan Moon-
dc.contributor.googleauthorSeung Jun Oh-
dc.contributor.googleauthorMinyoung Oh-
dc.contributor.googleauthorDuk L. Na-
dc.contributor.googleauthorChul Hyoung Lyoo-
dc.contributor.googleauthorEun-Joo Kim-
dc.contributor.googleauthorWilliam W. Seeley-
dc.contributor.googleauthorJae Seung Kim-
dc.contributor.googleauthorKyung Chan Choi-
dc.contributor.googleauthorSang Won Seo-
dc.identifier.doi10.1186/s12883-019-1434-z-
dc.contributor.localIdA01333-
dc.contributor.localIdA02485-
dc.contributor.localIdA02485-
dc.contributor.localIdA03920-
dc.contributor.localIdA03920-
dc.contributor.localIdA04695-
dc.contributor.localIdA04695-
dc.relation.journalcodeJ00368-
dc.identifier.eissn1471-2377-
dc.identifier.pmid31464590-
dc.subject.keywordCreutzfeldt-Jakob disease-
dc.subject.keywordFlortaucipir PET-
dc.subject.keywordMonoamine oxidase B-
dc.subject.keywordTHK5351 PET-
dc.contributor.alternativeNameLyoo, Chul Hyoung-
dc.contributor.affiliatedAuthor류철형-
dc.contributor.affiliatedAuthor유영훈-
dc.contributor.affiliatedAuthor유영훈-
dc.contributor.affiliatedAuthor조한나-
dc.contributor.affiliatedAuthor조한나-
dc.citation.volume19-
dc.citation.number1-
dc.citation.startPage211-
dc.identifier.bibliographicCitationBMC NEUROLOGY, Vol.19(1) : 211, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

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