Cited 8 times in
THK5351 and flortaucipir PET with pathological correlation in a Creutzfeldt-Jakob disease patient: a case report
DC Field | Value | Language |
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dc.contributor.author | 류철형 | - |
dc.contributor.author | 유영훈 | - |
dc.contributor.author | 조한나 | - |
dc.date.accessioned | 2019-12-18T00:58:32Z | - |
dc.date.available | 2019-12-18T00:58:32Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/173303 | - |
dc.description.abstract | BACKGROUND: THK5351 and flortaucipir tau ligands have high affinity for paired helical filament tau, yet diverse off-target bindings have been reported. Recent data support the hypothesis that THK5351 binds to monoamine oxidase B (MAO-B) expressed from reactive astrocytes and that flortaucipir has an affinity toward MAO-A and B; however, pathological evidence is lacking. We performed a head-to-head comparison of the two tau ligands in a sporadic Creutzfeldt-Jakob disease (CJD) patient and performed an imaging-pathological correlation study. CASE PRESENTATION: A 67-year-old man visited our clinic a history of 6 months of rapidly progressive dementia, visual disturbance, and akinetic mutism. Diffusion-weighted imaging showed cortical diffusion restrictions in the left temporo-parieto-occipital regions. 18F-THK5351 PET, but not 18F-flortaucipir PET showed high uptake in the left temporo-parieto-occipital regions, largely overlapping with the diffusion restricted areas. Cerebrospinal fluid analysis was weakly positive for 14-3-3 protein and pathogenic prion protein was found. The patient showed rapid cognitive decline along with myoclonic seizures and died 13 months after his first visit. A post-mortem study revealed immunoreactivity for PrPsc, no evidence of neurofibrillary tangles, and abundant astrocytosis which was reactive for MAO-B antibody. CONCLUSIONS: Our findings add pathological evidence that increased THK5351 uptake in sporadic CJD patients might be caused by an off-target binding driven by its high affinity for MAO-B. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | BioMed Central | - |
dc.relation.isPartOf | BMC NEUROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aminopyridines/pharmacology* | - |
dc.subject.MESH | Autopsy | - |
dc.subject.MESH | Brain/diagnostic imaging | - |
dc.subject.MESH | Brain/pathology | - |
dc.subject.MESH | Carbolines/pharmacology* | - |
dc.subject.MESH | Creutzfeldt-Jakob Syndrome/diagnostic imaging* | - |
dc.subject.MESH | Creutzfeldt-Jakob Syndrome/pathology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Monoamine Oxidase/metabolism | - |
dc.subject.MESH | Neurofibrillary Tangles/pathology | - |
dc.subject.MESH | Positron-Emission Tomography/methods* | - |
dc.subject.MESH | Quinolines/pharmacology* | - |
dc.subject.MESH | tau Proteins/metabolism | - |
dc.title | THK5351 and flortaucipir PET with pathological correlation in a Creutzfeldt-Jakob disease patient: a case report | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Hee Jin Kim | - |
dc.contributor.googleauthor | Hanna Cho | - |
dc.contributor.googleauthor | Seongbeom Park | - |
dc.contributor.googleauthor | Hyemin Jang | - |
dc.contributor.googleauthor | Young Hoon Ryu | - |
dc.contributor.googleauthor | Jae Yong Choi | - |
dc.contributor.googleauthor | Seung Hwan Moon | - |
dc.contributor.googleauthor | Seung Jun Oh | - |
dc.contributor.googleauthor | Minyoung Oh | - |
dc.contributor.googleauthor | Duk L. Na | - |
dc.contributor.googleauthor | Chul Hyoung Lyoo | - |
dc.contributor.googleauthor | Eun-Joo Kim | - |
dc.contributor.googleauthor | William W. Seeley | - |
dc.contributor.googleauthor | Jae Seung Kim | - |
dc.contributor.googleauthor | Kyung Chan Choi | - |
dc.contributor.googleauthor | Sang Won Seo | - |
dc.identifier.doi | 10.1186/s12883-019-1434-z | - |
dc.contributor.localId | A01333 | - |
dc.contributor.localId | A02485 | - |
dc.contributor.localId | A03920 | - |
dc.contributor.localId | A04695 | - |
dc.relation.journalcode | J00368 | - |
dc.identifier.eissn | 1471-2377 | - |
dc.identifier.pmid | 31464590 | - |
dc.subject.keyword | Creutzfeldt-Jakob disease | - |
dc.subject.keyword | Flortaucipir PET | - |
dc.subject.keyword | Monoamine oxidase B | - |
dc.subject.keyword | THK5351 PET | - |
dc.contributor.alternativeName | Lyoo, Chul Hyoung | - |
dc.contributor.affiliatedAuthor | 류철형 | - |
dc.contributor.affiliatedAuthor | 유영훈 | - |
dc.contributor.affiliatedAuthor | 조한나 | - |
dc.citation.volume | 19 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 211 | - |
dc.identifier.bibliographicCitation | BMC NEUROLOGY, Vol.19(1) : 211, 2019 | - |
dc.identifier.rimsid | 63870 | - |
dc.type.rims | ART | - |
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