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Treatment outcomes based on radiation therapy fields for bifocal germinoma: Synchronous or disseminated disease?

DC FieldValueLanguage
dc.contributor.author김동석-
dc.contributor.author서창옥-
dc.contributor.author윤홍인-
dc.contributor.author정승연-
dc.contributor.author한정우-
dc.date.accessioned2019-12-18T00:50:18Z-
dc.date.available2019-12-18T00:50:18Z-
dc.date.issued2019-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/173242-
dc.description.abstractIntracranial germinoma sometimes present as bifocal germinoma, and whether bifocal germinoma should be treated as a synchronous or disseminated disease remains unclear. This study aimed to determine the optimal treatment modality for bifocal germinoma. Patients with bifocal germinoma who received radiotherapy (RT) from March 1990 to August 2017 were included for analysis. A total of 21 patients were included. The median follow-up period was 76.2 months (range, 6.2-305.4 months). There were 17 patients who received cranio-spinal irradiation (CSI) with local RT; 3, whole ventricular RT (WVRT) with local RT; and 1, local RT only. Three recurrences occurred (1 patient each among those who underwent CSI, WVRT, and local RT). Recurrence in the patient who received CSI and who received WVRT occurred in the right thalamus and right frontal convexity, respectively. Meanwhile, the patient who received local RT showed not only a recurred lesion in the hypothalamus, but also cerebrospinal fluid seeding. For this patient, salvage CSI was performed and complete response was achieved after treatment. However, after 9 years and 6 months, he was diagnosed with glioblastoma and expired. As for toxicity, although 17 patients showed decrease in complete blood count levels during treatment, all patients recovered soon after treatment completion. Our findings suggest that bifocal germinoma may be considered as a disseminated disease when considering the patterns of failure according to RT fields. In addition, patients who received CSI showed low acute toxicity rates. However, further studies are necessary to confirm these findings.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleTreatment outcomes based on radiation therapy fields for bifocal germinoma: Synchronous or disseminated disease?-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학교실)-
dc.contributor.googleauthorSeung Yeun Chung-
dc.contributor.googleauthorJung Woo Han-
dc.contributor.googleauthorDong-Seok Kim-
dc.contributor.googleauthorHong In Yoon-
dc.contributor.googleauthorChang-Ok Suh-
dc.identifier.doi10.1371/journal.pone.0223481-
dc.contributor.localIdA00402-
dc.contributor.localIdA01919-
dc.contributor.localIdA01919-
dc.contributor.localIdA04777-
dc.contributor.localIdA04777-
dc.contributor.localIdA05411-
dc.contributor.localIdA05411-
dc.contributor.localIdA04325-
dc.contributor.localIdA04325-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid31581215-
dc.contributor.alternativeNameKim, Dong Seok-
dc.contributor.affiliatedAuthor김동석-
dc.contributor.affiliatedAuthor서창옥-
dc.contributor.affiliatedAuthor서창옥-
dc.contributor.affiliatedAuthor윤홍인-
dc.contributor.affiliatedAuthor윤홍인-
dc.contributor.affiliatedAuthor정승연-
dc.contributor.affiliatedAuthor정승연-
dc.contributor.affiliatedAuthor한정우-
dc.contributor.affiliatedAuthor한정우-
dc.citation.volume14-
dc.citation.number10-
dc.citation.startPagee0223481-
dc.identifier.bibliographicCitationPLOS ONE, Vol.14(10) : e0223481, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

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