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Adjuvant chemotherapy and survival among patients 70 years of age and younger with node-negative breast cancer and the 21-gene recurrence score of 26-30

DC Field Value Language
dc.contributor.author김승일-
dc.contributor.author박병우-
dc.contributor.author박세호-
dc.contributor.author조영업-
dc.date.accessioned2019-12-18T00:50:08Z-
dc.date.available2019-12-18T00:50:08Z-
dc.date.issued2019-
dc.identifier.issn1465-5411-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/173241-
dc.description.abstractBACKGROUND: The benefits of chemotherapy in node-negative, hormone receptor-positive, and human epidermal growth factor receptor 2 (HER2)-negative breast cancer patients with the 21-gene recurrence score (RS) of 18-30, particularly those with RS 26-30, are not known. METHODS: Using the Surveillance, Epidemiology, and End Results (SEER) data, we retrospectively identified 29,137 breast cancer patients with the 21-gene RS of 18-30 diagnosed between 2004 and 2015. Mortality risks according to the RS and chemotherapy use were compared by the Kaplan-Meier method and Cox's proportional hazards model. RESULTS: Among the breast cancer patients with the RS 18-30, 21% of them had RS 26-30. Compared to breast cancer patients with RS 18-25, patients with RS 26-30 had more aggressive tumor characteristics and chemotherapy use and increased risk of breast cancer-specific mortality and overall mortality. In breast cancer patients who were aged ≤ 70 years and had RS of 26-30, chemotherapy administration was associated with a 32% lower risk of breast cancer-specific mortality (hazard ratio [HR], 0.68; 95% confidence interval [CI], 0.47-0.99) and a 42% lower risk of overall mortality (HR, 0.58; 95% CI, 0.44-0.76). Survival benefits were most pronounced in breast cancer patients who were younger or had grade III tumor. CONCLUSIONS: The 21-gene RS of 18-30 showed heterogeneous outcomes, and the RS 26-30 was a significant prognostic factor for an increased risk of mortality. Adjuvant chemotherapy could improve the survival of node-negative, hormone receptor-positive, and HER2-negative breast cancer patients with the 21-gene RS 26-30 and should be considered for patients, especially younger patients or patients with high-grade tumors.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBioMed Central Ltd-
dc.relation.isPartOfBREAST CANCER RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleAdjuvant chemotherapy and survival among patients 70 years of age and younger with node-negative breast cancer and the 21-gene recurrence score of 26-30-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorSeho Park-
dc.contributor.googleauthorYunan Han-
dc.contributor.googleauthorYing Liu-
dc.contributor.googleauthorAdetunji T. Toriola-
dc.contributor.googleauthorLindsay L. Peterson-
dc.contributor.googleauthorGraham A. Colditz-
dc.contributor.googleauthorSeung Il Kim-
dc.contributor.googleauthorYoung Up Cho-
dc.contributor.googleauthorByeong-Woo Park-
dc.contributor.googleauthorYikyung Park-
dc.identifier.doi10.1186/s13058-019-1190-4-
dc.contributor.localIdA00658-
dc.contributor.localIdA01475-
dc.contributor.localIdA01475-
dc.contributor.localIdA01524-
dc.contributor.localIdA01524-
dc.contributor.localIdA05420-
dc.contributor.localIdA05420-
dc.relation.journalcodeJ00402-
dc.identifier.eissn1465-542X-
dc.identifier.pmid31619259-
dc.subject.keyword21-gene recurrence score-
dc.subject.keywordBreast cancer-
dc.subject.keywordChemotherapy-
dc.subject.keywordSurvival-
dc.contributor.alternativeNameKim, Seung Il-
dc.contributor.affiliatedAuthor김승일-
dc.contributor.affiliatedAuthor박병우-
dc.contributor.affiliatedAuthor박병우-
dc.contributor.affiliatedAuthor박세호-
dc.contributor.affiliatedAuthor박세호-
dc.contributor.affiliatedAuthor조영업-
dc.contributor.affiliatedAuthor조영업-
dc.citation.volume21-
dc.citation.number1-
dc.citation.startPage110-
dc.identifier.bibliographicCitationBREAST CANCER RESEARCH, Vol.21(1) : 110, 2019-
dc.identifier.rimsid63688-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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