Cited 19 times in
Longitudinal decline in lung function: a community-based cohort study in Korea
DC Field | Value | Language |
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dc.contributor.author | 김영삼 | - |
dc.contributor.author | 임아영 | - |
dc.contributor.author | 장준 | - |
dc.contributor.author | 정지예 | - |
dc.date.accessioned | 2019-12-18T00:46:30Z | - |
dc.date.available | 2019-12-18T00:46:30Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/173214 | - |
dc.description.abstract | Progressive decline in lung function is the hallmark of chronic obstructive pulmonary disease (COPD). We aimed to assess the rate of decline in forced expiratory volume in 1 second (FEV1) in patients from a community cohort database in Korea. 5,865 subjects aged 40-69 years from the Ansung-Ansan cohort database I-III (2001-2006) were included in this study. We assessed the annual rate of decline in FEV1 over time in relation to smoking status, patient sex, and presence or absence of pre-bronchodilator airflow limitation using a generalized additive mixed model. The mean follow-up duration was 3.8 years. The annual mean decline in FEV1 in the entire cohort was significantly more rapid for men than women (31.3 mL vs 27.0 mL, P = 0.003). Among men without pre-bronchodilator airflow limitation, annual mean declines in FEV1 were 31.5, 35.5, and 40.1 mL for never smokers, former smokers (P = 0.09 vs. never smokers), and current smokers (P < 0.001 vs. never smokers), respectively; and 23.4, 19.7, and 33.9 mL, respectively, for men with pre-bronchodilator airflow limitation. Thus, among Korean males, smoking accelerates lung function decline over time whereas smoking cessation slows the rate of FEV1 decline regardless of pre-bronchodilator airflow limitation. This underscores the importance of smoking cessation in Koreans. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Longitudinal decline in lung function: a community-based cohort study in Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Ah Young Leem | - |
dc.contributor.googleauthor | Boram Park | - |
dc.contributor.googleauthor | Young Sam Kim | - |
dc.contributor.googleauthor | Joon Chang | - |
dc.contributor.googleauthor | Sungho Won | - |
dc.contributor.googleauthor | Ji Ye Jung | - |
dc.identifier.doi | 10.1038/s41598-019-49598-9 | - |
dc.contributor.localId | A00707 | - |
dc.contributor.localId | A03382 | - |
dc.contributor.localId | A03472 | - |
dc.contributor.localId | A03735 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 31541126 | - |
dc.contributor.alternativeName | Kim, Young Sam | - |
dc.contributor.affiliatedAuthor | 김영삼 | - |
dc.contributor.affiliatedAuthor | 임아영 | - |
dc.contributor.affiliatedAuthor | 장준 | - |
dc.contributor.affiliatedAuthor | 정지예 | - |
dc.citation.volume | 9 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | e13614 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.9(1) : e13614, 2019 | - |
dc.identifier.rimsid | 63240 | - |
dc.type.rims | ART | - |
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