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Brief Report: Malignancies in Adults Living With HIV in Asia

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dc.contributor.author최준용-
dc.date.accessioned2019-12-18T00:46:18Z-
dc.date.available2019-12-18T00:46:18Z-
dc.date.issued2019-
dc.identifier.issn1525-4135-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/173211-
dc.description.abstractBACKGROUND: Hematological malignancies have continued to be highly prevalent among people living with HIV (PLHIV). This study assessed the occurrence of, risk factors for, and outcomes of hematological and nonhematological malignancies in PLHIV in Asia. METHODS: Incidence of malignancy after cohort enrollment was evaluated. Factors associated with development of hematological and nonhematological malignancy were analyzed using competing risk regression and survival time using Kaplan-Meier. RESULTS: Of 7455 patients, 107 patients (1%) developed a malignancy: 34 (0.5%) hematological [0.08 per 100 person-years (/100PY)] and 73 (1%) nonhematological (0.17/100PY). Of the hematological malignancies, non-Hodgkin lymphoma was predominant (n = 26, 76%): immunoblastic (n = 6, 18%), Burkitt (n = 5, 15%), diffuse large B-cell (n = 5, 15%), and unspecified (n = 10, 30%). Others include central nervous system lymphoma (n = 7, 21%) and myelodysplastic syndrome (n = 1, 3%). Nonhematological malignancies were mostly Kaposi sarcoma (n = 12, 16%) and cervical cancer (n = 10, 14%). Risk factors for hematological malignancy included age >50 vs. ≤30 years [subhazard ratio (SHR) = 6.48, 95% confidence interval (CI): 1.79 to 23.43] and being from a high-income vs. a lower-middle-income country (SHR = 3.97, 95% CI: 1.45 to 10.84). Risk was reduced with CD4 351-500 cells/µL (SHR = 0.20, 95% CI: 0.05 to 0.74) and CD4 >500 cells/µL (SHR = 0.14, 95% CI: 0.04 to 0.78), compared to CD4 ≤200 cells/µL. Similar risk factors were seen for nonhematological malignancy, with prior AIDS diagnosis showing a weak association. Patients diagnosed with a hematological malignancy had shorter survival time compared to patients diagnosed with a nonhematological malignancy. CONCLUSIONS: Nonhematological malignancies were common but non-Hodgkin lymphoma was more predominant in our cohort. PLHIV from high-income countries were more likely to be diagnosed, indicating a potential underdiagnosis of cancer in low-income settings.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins, Inc.-
dc.relation.isPartOfJAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAsia/epidemiology-
dc.subject.MESHCD4 Lymphocyte Count-
dc.subject.MESHCohort Studies-
dc.subject.MESHDatabases, Factual-
dc.subject.MESHHIV Infections/complications*-
dc.subject.MESHHIV Infections/epidemiology*-
dc.subject.MESHHumans-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHNeoplasms/complications*-
dc.subject.MESHNeoplasms/epidemiology*-
dc.subject.MESHRisk Factors-
dc.subject.MESHSurvival Analysis-
dc.titleBrief Report: Malignancies in Adults Living With HIV in Asia-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJiamsakul, Awachana PhDa-
dc.contributor.googleauthorPolizzotto, Mark MBBSa-
dc.contributor.googleauthorWen-Wei Ku, Stephane MDb-
dc.contributor.googleauthorTanuma, Junko MDc-
dc.contributor.googleauthorHui, Eugenie MDd-
dc.contributor.googleauthorChaiwarith, Romanee MDe-
dc.contributor.googleauthorKiertiburanakul, Sasisopin MDf-
dc.contributor.googleauthorAvihingasanon, Anchalee MDg-
dc.contributor.googleauthorYunihastuti, Evy MDh-
dc.contributor.googleauthorKumarasamy, Nagalingeswaran MDi-
dc.contributor.googleauthorLy, Penh Sun MDj-
dc.contributor.googleauthorPujari, Sanjay MDk-
dc.contributor.googleauthorDitangco, Rossana MDl-
dc.contributor.googleauthorDo, Cuong Duy MDm-
dc.contributor.googleauthorMerati, Tuti Parwati MDn-
dc.contributor.googleauthorKantipong, Pacharee MDo-
dc.contributor.googleauthorZhang, Fujie MDp-
dc.contributor.googleauthorVan Nguyen, Kinh MDq-
dc.contributor.googleauthorKamarulzaman, Adeeba MDr-
dc.contributor.googleauthorChoi, Jun Yong MDs-
dc.contributor.googleauthorSim, Benedict L.H. MDt-
dc.contributor.googleauthorNg, Oon Tek MDu-
dc.contributor.googleauthorRoss, Jeremy MBBSv-
dc.contributor.googleauthorWong, Wingwai-
dc.identifier.doi10.1097/QAI.0000000000001918-
dc.contributor.localIdA04191-
dc.relation.journalcodeJ01195-
dc.identifier.eissn1944-7884-
dc.identifier.pmid30531303-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00126334-201903010-00010&LSLINK=80&D=ovft-
dc.contributor.alternativeNameChoi, Jun Yong-
dc.contributor.affiliatedAuthor최준용-
dc.citation.volume80-
dc.citation.number3-
dc.citation.startPage301-
dc.citation.endPage307-
dc.identifier.bibliographicCitationJAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, Vol.80(3) : 301-307, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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