Cited 25 times in
Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3
DC Field | Value | Language |
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dc.contributor.author | 이재현 | - |
dc.date.accessioned | 2019-12-18T00:42:20Z | - |
dc.date.available | 2019-12-18T00:42:20Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/173183 | - |
dc.description.abstract | TGF-β1 is a critical mediator of tissue fibrosis in health and disease whose effects are augmented by chitinase 1 (CHIT1). However, the mechanisms that CHIT1 uses to regulate TGF-β1-mediated fibrotic responses have not been defined. Here, we demonstrate that CHIT1 enhances TGF-β1-stimulated fibrotic cellular and tissue responses and TGF-β1 signaling. Importantly, we also demonstrate that these effects are mediated by the ability of CHIT1 to inhibit TGF-β1 induction of its feedback inhibitor, SMAD7. CHIT1 also interacted with TGF-β receptor associated protein 1 (TGFBRAP1) and forkhead box O3 (FOXO3) with TGFBRAP1 playing a critical role in CHIT1 enhancement of TGF-β1 signaling and effector responses and FOXO3 playing a critical role in TGF-β1 induction of SMAD7. These pathways were disease relevant because the levels of CHIT1 were increased and inversely correlated with SMAD7 in tissues from patients with idiopathic pulmonary fibrosis or scleroderma-associated interstitial lung disease. These studies demonstrate that CHIT1 regulates TGF-β1/SMAD7 axis via TGFBRAP1 and FOXO3 and highlight the importance of these pathways in the pathogenesis of pulmonary fibrosis. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Life Science Alliance | - |
dc.relation.isPartOf | Life Science Alliance | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Chang-Min Lee | - |
dc.contributor.googleauthor | Chuan-Hua He | - |
dc.contributor.googleauthor | Jin Wook Park | - |
dc.contributor.googleauthor | Jae Hyun Lee | - |
dc.contributor.googleauthor | Suchita Kamle | - |
dc.contributor.googleauthor | Bing Ma | - |
dc.contributor.googleauthor | Bedia Akosman | - |
dc.contributor.googleauthor | Roberto Cotez | - |
dc.contributor.googleauthor | Emily Chen | - |
dc.contributor.googleauthor | Yang Zhou | - |
dc.contributor.googleauthor | Erica L Herzog | - |
dc.contributor.googleauthor | Changwan Ryu | - |
dc.contributor.googleauthor | Xueyan Peng | - |
dc.contributor.googleauthor | Ivan O Rosas | - |
dc.contributor.googleauthor | Sergio Poli | - |
dc.contributor.googleauthor | Carol Feghali Bostwick | - |
dc.contributor.googleauthor | Augustine M Choi | - |
dc.contributor.googleauthor | Jack A Elias | - |
dc.contributor.googleauthor | Chun Geun Lee | - |
dc.identifier.doi | 10.26508/lsa.201900350 | - |
dc.contributor.localId | A03086 | - |
dc.relation.journalcode | J03729 | - |
dc.identifier.eissn | 2575-1077 | - |
dc.identifier.pmid | 31085559 | - |
dc.contributor.alternativeName | Lee, Jae Hyun | - |
dc.contributor.affiliatedAuthor | 이재현 | - |
dc.citation.volume | 2 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | e201900350 | - |
dc.identifier.bibliographicCitation | Life Science Alliance, Vol.2(3) : e201900350, 2019 | - |
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