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Long-Term Mortality and Prognostic Factors in Aspiration Pneumonia

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dc.contributor.author이수환-
dc.date.accessioned2019-12-18T00:40:14Z-
dc.date.available2019-12-18T00:40:14Z-
dc.date.issued2019-
dc.identifier.issn1525-8610-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/173165-
dc.description.abstractOBJECTIVES: Aspiration pneumonia is a leading cause of death among older patients; however, little is known about the long-term mortality in aspiration pneumonia. The purpose of this study was to evaluate long-term mortality and its associated factors in patients with aspiration pneumonia. DESIGN: Retrospective cohort study. SETTING AND PARTICIPANTS: In total, 550 patients with aspiration pneumonia (median age: 78.0 years, 66.4% male) with compatible clinical symptoms and chest computed tomography images were enrolled at a single tertiary center from 2006 to 2016. MEASURES: The 1-, 3-, and 5-year mortality rates were evaluated for all patients. The prognostic factors for 1-year and 5-year mortality were also evaluated using Cox proportional hazard models. RESULTS: A total of 441 (80.2%) patients died during a median follow-up of 50.7 weeks. The 1-, 3-, and 5-year mortality rates were 49.0%, 67.1%, and 76.9%, respectively. Multivariate analysis identified 5 risk factors for 1-year mortality of male sex [hazard ratio (HR) 1.533, P = .003], low body mass index (HR 0.934, P = .002), hypoalbuminemia, anemia (0.973, P = .032), and mechanical ventilation (HR 2.052, P < .001), which were also independent prognostic factors for 5-year mortality. During the follow-up period, 133 (24.2%) patients experienced recurrent aspiration pneumonia. However, Kaplan-Meier analysis showed no significant differences in survival curves between patients with single and recurrent aspiration pneumonia (P = .371). CONCLUSIONS/IMPLICATIONS: Long-term prognosis of aspiration pneumonia was poor as a result of underlying morbidity instead of the aspiration pneumonia itself. Our findings suggest that prognostic indices for patients with aspiration pneumonia including the patient's underlying conditions should be devised.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfJOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleLong-Term Mortality and Prognostic Factors in Aspiration Pneumonia-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorHee-Young Yoon-
dc.contributor.googleauthorSung Shine Shim-
dc.contributor.googleauthorSoo Jung Kim-
dc.contributor.googleauthorJin Hwa Lee-
dc.contributor.googleauthorJung Hyun Chang-
dc.contributor.googleauthorSu Hwan Lee-
dc.contributor.googleauthorYon Ju Ryu-
dc.identifier.doi10.1016/j.jamda.2019.03.029-
dc.contributor.localIdA02904-
dc.relation.journalcodeJ01775-
dc.identifier.eissn1538-9375-
dc.identifier.pmid31080159-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S152586101930324X-
dc.subject.keywordAspiration pneumonia-
dc.subject.keywordelderly-
dc.subject.keywordmortality-
dc.subject.keywordprognosis-
dc.subject.keywordrecurrent aspiration-
dc.contributor.alternativeNameLee, Su Hwan-
dc.contributor.affiliatedAuthor이수환-
dc.citation.volume20-
dc.citation.number9-
dc.citation.startPage1098-
dc.citation.endPage1104.e4-
dc.identifier.bibliographicCitationJOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, Vol.20(9) : 1098-1104.e4, 2019-
dc.identifier.rimsid63837-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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