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A Genome-wide Functional Signature Ontology Map and Applications to Natural Product Mechanism of Action Discovery

DC FieldValueLanguage
dc.contributor.author김현석-
dc.date.accessioned2019-12-18T00:36:54Z-
dc.date.available2019-12-18T00:36:54Z-
dc.date.issued2019-
dc.identifier.issn2451-9456-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/173137-
dc.description.abstractGene expression signature-based inference of functional connectivity within and between genetic perturbations, chemical perturbations, and disease status can lead to the development of actionable hypotheses for gene function, chemical modes of action, and disease treatment strategies. Here, we report a FuSiOn-based genome-wide integration of hypomorphic cellular phenotypes that enables functional annotation of gene network topology, assignment of mechanistic hypotheses to genes of unknown function, and detection of cooperativity among cell regulatory systems. Dovetailing genetic perturbation data with chemical perturbation phenotypes allowed simultaneous generation of mechanism of action hypotheses for thousands of uncharacterized natural products fractions (NPFs). The predicted mechanism of actions span a broad spectrum of cellular mechanisms, many of which are not currently recognized as "druggable." To enable use of FuSiOn as a hypothesis generation resource, all associations and analyses are available within an open source web-based GUI (http://fusion.yuhs.ac).-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfCell Chemical Biology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleA Genome-wide Functional Signature Ontology Map and Applications to Natural Product Mechanism of Action Discovery-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentBioMedical Science Institute (의생명과학부)-
dc.contributor.googleauthorElizabeth A. McMillan-
dc.contributor.googleauthorGino Kwon-
dc.contributor.googleauthorJean R. Clemenceau-
dc.contributor.googleauthorKurt W. Fisher-
dc.contributor.googleauthorRachel M. Vaden-
dc.contributor.googleauthorAnam F. Shaikh-
dc.contributor.googleauthorBeth K. Neilsen-
dc.contributor.googleauthorDavid Kelly-
dc.contributor.googleauthorMalia B. Potts-
dc.contributor.googleauthorYeo-Jin Sung-
dc.contributor.googleauthorSaurabh Mendiratta-
dc.contributor.googleauthorSuzie K. Hight-
dc.contributor.googleauthorYunji Lee-
dc.contributor.googleauthorJohn B. MacMillan-
dc.contributor.googleauthorRobert E. Lewis-
dc.contributor.googleauthorHyun Seok Kim-
dc.contributor.googleauthorMichael A. White-
dc.identifier.doi10.1016/j.chembiol.2019.07.008-
dc.contributor.localIdA01111-
dc.relation.journalcodeJ00479-
dc.identifier.pmid31378711-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S2451945619302399-
dc.subject.keywordcell regulatory networks-
dc.subject.keywordchemical genetics-
dc.subject.keywordfunctional genomics-
dc.subject.keywordmechanism of action-
dc.subject.keywordnatural products-
dc.subject.keywordnetwork pharmacology-
dc.contributor.alternativeNameKim, Hyun Seok-
dc.contributor.affiliatedAuthor김현석-
dc.citation.volume26-
dc.citation.number10-
dc.citation.startPage1380-
dc.citation.endPage1392.e6-
dc.identifier.bibliographicCitationCell Chemical Biology, Vol.26(10) : 1380-1392.e6, 2019-
dc.identifier.rimsid63686-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

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