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Effects of Lewy body disease and Alzheimer disease on brain atrophy and cognitive dysfunction

DC FieldValueLanguage
dc.contributor.author손영호-
dc.contributor.author예병석-
dc.contributor.author유한수-
dc.contributor.author윤미진-
dc.contributor.author이필휴-
dc.contributor.author정석종-
dc.date.accessioned2019-12-18T00:36:10Z-
dc.date.available2019-12-18T00:36:10Z-
dc.date.issued2019-
dc.identifier.issn0028-3878-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/173132-
dc.description.abstractOBJECTIVES: To investigate the independent and interaction effects of Alzheimer disease (AD) and Lewy body disease (LBD) on cognition and brain atrophy. METHODS: We consecutively recruited 38 controls and 108 patients with AD-related cognitive impairment (ADCI) and/or LBD-related cognitive impairment (LBCI) from university-based dementia and movement clinics. Diagnoses of ADCI and LBCI were supported by 18F-florbetaben PET and 18F-N-(3-fluoropropyl)-2β-carbon ethoxy-3β-(4-iodophenyl) nortropane-PET, respectively. There were 38 controls, 26 patients with pure ADCI (18 mild cognitive impairment [MCI] and 8 dementia), 28 patients with pure LBCI (13 MCI and 15 dementia), and 54 patients with mixed ADCI and LBCI (17 MCI and 37 dementia). We performed group-wise comparisons for neuropsychological z scores and regional cortical thickness. We also evaluated the effects of ADCI and LBCI using general linear models. RESULTS: Compared to the controls, patients in the pure ADCI group and pure LBCI group had focused cortical thinning in the bilateral entorhinal/right anterior temporal cortices and bilateral anteromedial temporal/basal frontal cortices, respectively, while the mixed disease group had additional cortical thinning in the widespread association cortices. The independent effects of ADCI and LBCI on regional cortical thinning overlapped in the widespread association cortices, especially at the bilateral temporoparietal junction and parietal cortices. ADCI and LBCI had independent detrimental effects on the copying item of the Rey-Osterrieth Complex Figure Test. CONCLUSIONS: Concomitant ADCI and LBCI are associated with the accentuation of neurodegeneration to widespread association cortices, and both diseases contribute to visuospatial dysfunction.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfNEUROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEffects of Lewy body disease and Alzheimer disease on brain atrophy and cognitive dysfunction-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorSung Woo Kang-
dc.contributor.googleauthorSeun Jeon-
dc.contributor.googleauthorHan Soo Yoo-
dc.contributor.googleauthorSeok Jong Chung-
dc.contributor.googleauthorPhil Hyu Lee-
dc.contributor.googleauthorYoung H. Sohn-
dc.contributor.googleauthorMijin Yun-
dc.contributor.googleauthorAlan C. Evans-
dc.contributor.googleauthorByoung Seok Ye-
dc.identifier.doi10.1212/WNL.0000000000007373-
dc.contributor.localIdA01982-
dc.contributor.localIdA04603-
dc.contributor.localIdA04603-
dc.contributor.localIdA05367-
dc.contributor.localIdA05367-
dc.contributor.localIdA02550-
dc.contributor.localIdA02550-
dc.contributor.localIdA03270-
dc.contributor.localIdA03270-
dc.contributor.localIdA04666-
dc.contributor.localIdA04666-
dc.relation.journalcodeJ02340-
dc.identifier.eissn1526-632X-
dc.identifier.pmid30944239-
dc.identifier.urlhttps://n.neurology.org/content/92/17/e2015.long-
dc.contributor.alternativeNameSohn, Young Ho-
dc.contributor.affiliatedAuthor손영호-
dc.contributor.affiliatedAuthor예병석-
dc.contributor.affiliatedAuthor예병석-
dc.contributor.affiliatedAuthor유한수-
dc.contributor.affiliatedAuthor유한수-
dc.contributor.affiliatedAuthor윤미진-
dc.contributor.affiliatedAuthor윤미진-
dc.contributor.affiliatedAuthor이필휴-
dc.contributor.affiliatedAuthor이필휴-
dc.contributor.affiliatedAuthor정석종-
dc.contributor.affiliatedAuthor정석종-
dc.citation.volume92-
dc.citation.number17-
dc.citation.startPagee2015-
dc.citation.endPagee2026-
dc.identifier.bibliographicCitationNEUROLOGY, Vol.92(17) : e2015-e2026, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

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