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Clinical relevance of amnestic versus non-amnestic mild cognitive impairment subtyping in Parkinson's disease
DC Field | Value | Language |
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dc.contributor.author | 이필휴 | - |
dc.contributor.author | 정석종 | - |
dc.contributor.author | 유한수 | - |
dc.date.accessioned | 2019-12-18T00:35:01Z | - |
dc.date.available | 2019-12-18T00:35:01Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1351-5101 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/173116 | - |
dc.description.abstract | BACKGROUND AND PURPOSE: To clarify whether subtyping of amnestic and non-amnestic mild cognitive impairment (MCI) is clinically relevant in Parkinson's disease (PD) by analyzing patterns of neuroimaging and longitudinal cognitive changes. METHODS: We performed comparative analyses of cortical thickness, hippocampal volume, white matter integrity and resting-state functional connectivity between the patients with de-novo PD with amnestic MCI (PD-aMCI) (n = 50) and non-amnestic MCI (PD-naMCI) (n = 50) subtypes. Additionally, we assessed the longitudinal rate of cognitive decline in each cognitive domain over time and the rate of dementia conversion in patients with de-novo PD-aMCI (n = 125) and PD-naMCI (n = 61). RESULTS: The demographic data showed that scores in memory domains were lower in the PD-aMCI group compared with the PD-naMCI group. There were no significant differences in cortical thickness, hippocampal volume and white matter integrity between the two groups, although the PD-aMCI group exhibited more cortical thinning and hippocampal atrophy relative to the control group. The PD-aMCI group exhibited increased functional connectivity in the left posterior parietal region with the salience network relative to the PD-naMCI group. The longitudinal cognitive assessment demonstrated that patients with PD-aMCI exhibited a more rapid cognitive decline in frontal/executive function than those with PD-naMCI (P = 0.022). In addition, the PD-aMCI group had a higher risk of dementia conversion than the PD-naMCI group. CONCLUSIONS: This study suggests that the designation of PD-MCI subtypes based on memory function would highlight the heterogeneity of functional correlates as well as the longitudinal cognitive prognosis. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF NEUROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Clinical relevance of amnestic versus non-amnestic mild cognitive impairment subtyping in Parkinson's disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | S. J. Chung | - |
dc.contributor.googleauthor | Y.-H. Park | - |
dc.contributor.googleauthor | H. J. Yun | - |
dc.contributor.googleauthor | H. Kwon | - |
dc.contributor.googleauthor | H. S. Yoo | - |
dc.contributor.googleauthor | Y. H. Sohn | - |
dc.contributor.googleauthor | J.-M. Lee | - |
dc.contributor.googleauthor | P. H. Lee | - |
dc.identifier.doi | 10.1111/ene.13886 | - |
dc.contributor.localId | A03270 | - |
dc.contributor.localId | A04666 | - |
dc.relation.journalcode | J00830 | - |
dc.identifier.eissn | 1468-1331 | - |
dc.identifier.pmid | 30565368 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/full/10.1111/ene.13886 | - |
dc.subject.keyword | Parkinson's disease | - |
dc.subject.keyword | cognitive decline | - |
dc.subject.keyword | memory | - |
dc.subject.keyword | mild cognitive impairment | - |
dc.subject.keyword | neuroimaging | - |
dc.contributor.alternativeName | Lee, Phil Hyu | - |
dc.contributor.affiliatedAuthor | 이필휴 | - |
dc.contributor.affiliatedAuthor | 정석종 | - |
dc.citation.volume | 26 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 766 | - |
dc.citation.endPage | 773 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF NEUROLOGY, Vol.26(5) : 766-773, 2019 | - |
dc.identifier.rimsid | 64194 | - |
dc.type.rims | ART | - |
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