Cited 21 times in
Characteristics and outcomes of HFpEF with declining ejection fraction
DC Field | Value | Language |
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dc.contributor.author | 강석민 | - |
dc.date.accessioned | 2019-12-18T00:27:55Z | - |
dc.date.available | 2019-12-18T00:27:55Z | - |
dc.date.issued | 2020-02 | - |
dc.identifier.issn | 1861-0684 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/173060 | - |
dc.description.abstract | OBJECTIVE: Some patients with heart failure with preserved ejection fraction (HFpEF) experience declining of left-ventricular ejection fraction (LVEF) during follow-up. We aim to investigate the characteristics and outcomes of patients with HF with declining ejection fraction (HFdEF). METHODS: We analyzed a prospective, nationwide multicenter cohort with consecutive patients with acute HF enrolled from March 2011 to December 2014. HFpEF was defined as LVEF ≥ 50% at index admission. After 1 year, HFpEF patients were further classified as HFdEF (LVEF ≥ 50% at admission and < 50% at 1 year), and persistent HFpEF (LVEF ≥ 50% both at admission and 1 year). Primary outcome was 4-year all-cause mortality according to HF type from HFdEF diagnosis. RESULTS: Of patients with HFpEF, 426 (90.4%) were diagnosed as having persistent HFpEF and 45 (9.6%) as having HFdEF. Natriuretic peptide level was an independent predictor of HFdEF (natriuretic peptide level > median: odds ratio: 3.20, 95% confidence interval [CI]: 1.42-7.25, P = 0.005). During 4-year follow-up, patients with HFdEF had higher mortality than those with persistent HFpEF (Log-rank P < 0.001). After adjustment, HFdEF was associated with an almost twofold increased risk for mortality (hazard ratio 1.82, 95% CI 1.13-2.96, P = 0.015). The use of beta-blockers, renin-angiotensin system inhibitors, and mineralocorticoid receptor antagonists was not associated with improved prognosis of patients with HFdEF. CONCLUSIONS: HFdEF is a distinct HF type with grave outcomes. Further investigations that focus on HFdEF are warranted to better understand and develop treatment strategies for these high-risk patients. CLINICAL TRIAL REGISTRATION: ClinicalTrial.gov identifier: NCT01389843. URL: https://clinicaltrials.gov/ct2/show/NCT01389843. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | CLINICAL RESEARCH IN CARDIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Characteristics and outcomes of HFpEF with declining ejection fraction | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jin Joo Park | - |
dc.contributor.googleauthor | Chan Soon Park | - |
dc.contributor.googleauthor | Alexandre Mebazaa | - |
dc.contributor.googleauthor | Il-Young Oh | - |
dc.contributor.googleauthor | Hyun-Ah Park | - |
dc.contributor.googleauthor | Hyun-Jai Cho | - |
dc.contributor.googleauthor | Hae-Young Lee | - |
dc.contributor.googleauthor | Kye Hun Kim | - |
dc.contributor.googleauthor | Byung-Su Yoo | - |
dc.contributor.googleauthor | Seok-Min Kang | - |
dc.contributor.googleauthor | Sang Hong Baek | - |
dc.contributor.googleauthor | Eun-Seok Jeon | - |
dc.contributor.googleauthor | Jae-Joong Kim | - |
dc.contributor.googleauthor | Myeong-Chan Cho | - |
dc.contributor.googleauthor | Shung Chull Chae | - |
dc.contributor.googleauthor | Byung-Hee Oh | - |
dc.contributor.googleauthor | Dong-Ju Choi | - |
dc.identifier.doi | 10.1007/s00392-019-01505-y | - |
dc.contributor.localId | A00037 | - |
dc.relation.journalcode | J03070 | - |
dc.identifier.eissn | 1861-0692 | - |
dc.identifier.pmid | 31267239 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00392-019-01505-y | - |
dc.subject.keyword | Heart failure with declining ejection fraction | - |
dc.subject.keyword | Mortality | - |
dc.subject.keyword | Predictor | - |
dc.subject.keyword | Prognosis | - |
dc.subject.keyword | Treatment | - |
dc.contributor.alternativeName | Kang, Seok Min | - |
dc.contributor.affiliatedAuthor | 강석민 | - |
dc.citation.volume | 109 | - |
dc.citation.startPage | 225 | - |
dc.citation.endPage | 234 | - |
dc.identifier.bibliographicCitation | CLINICAL RESEARCH IN CARDIOLOGY, Vol.109 : 225-234, 2020-02 | - |
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