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Staged partial hepatectomy versus transarterial chemoembolization for the treatment of spontaneous hepatocellular carcinoma rupture: a multicenter analysis in Korea

DC FieldValueLanguage
dc.contributor.author김도영-
dc.contributor.author김승업-
dc.contributor.author김재근-
dc.contributor.author박준용-
dc.contributor.author안상훈-
dc.contributor.author윤동섭-
dc.contributor.author최기홍-
dc.contributor.author최진섭-
dc.contributor.author한광협-
dc.date.accessioned2019-12-18T00:24:40Z-
dc.date.available2019-12-18T00:24:40Z-
dc.date.issued2019-
dc.identifier.issn2288-6575-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/173036-
dc.description.abstractPurpose: The aim of this study was to identify the prognostic factors and compare the long-term outcomes of staged hepatectomy and transarterial chemoembolization (TACE) for patients with spontaneous rupture of hepatocellular carcinoma (HCC). Methods: This study is a multicenter, retrospective analysis of patients with newly diagnosed ruptured HCC. To compare overall survival between staged hepatectomy group and TACE alone group, we performed propensity score-matching to adjust for significant differences in patient characteristics. To identify prognostic factors, the clinical characteristics at the time of diagnosis of tumor rupture were investigated using Cox-regression analysis. Results: From 2000 to 2014, 172 consecutive patients with newly diagnosed ruptured HCC were treated in 6 Korean centers. One hundred seventeen patients with Child-Pugh class A disease were identified; of which 112 were initially treated with transcatheter arterial embolization (TAE) for hemostasis and five underwent emergency surgery for bleeder ligation. Of the 112 patients treated with TAE, 44 underwent staged hepatectomy, 61 received TACE alone, and 7 received conservative treatment after TAE. Those that underwent staged hepatectomy had significantly higher overall survival than those that underwent TACE alone before matching (P < 0.001) and after propensity score-matching (P = 0.006). Multivariate analysis showed that type of treatment, presence of portal vein thrombosis, pretreatment transfusion >1,200 mL, and tumor size >5 cm were associated with poor overall survival. Conclusion: Staged hepatectomy may offer better long-term survival than TACE alone for spontaneous rupture of HCC. Staged hepatectomy should be considered in spontaneous rupture of HCC with resectable tumor and preserved liver function.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherKorean Surgical Society-
dc.relation.isPartOfANNALS OF SURGICAL TREATMENT AND RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleStaged partial hepatectomy versus transarterial chemoembolization for the treatment of spontaneous hepatocellular carcinoma rupture: a multicenter analysis in Korea-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorHyung Soon Lee-
dc.contributor.googleauthorGi Hong Choi-
dc.contributor.googleauthorJin Sub Choi-
dc.contributor.googleauthorKwang-Hyub Han-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorDo Young Kim-
dc.contributor.googleauthorJun Yong Park-
dc.contributor.googleauthorSeung Up Kim-
dc.contributor.googleauthorSung Hoon Kim-
dc.contributor.googleauthorDong Sup Yoon-
dc.contributor.googleauthorJae Keun Kim-
dc.contributor.googleauthorJong Won Choi-
dc.contributor.googleauthorSoon Sun Kim-
dc.contributor.googleauthorHana Park-
dc.identifier.doi10.4174/astr.2019.96.6.275-
dc.contributor.localIdA00385-
dc.contributor.localIdA00654-
dc.contributor.localIdA00654-
dc.contributor.localIdA00857-
dc.contributor.localIdA00857-
dc.contributor.localIdA01675-
dc.contributor.localIdA01675-
dc.contributor.localIdA02226-
dc.contributor.localIdA02226-
dc.contributor.localIdA02548-
dc.contributor.localIdA02548-
dc.contributor.localIdA04046-
dc.contributor.localIdA04046-
dc.contributor.localIdA04199-
dc.contributor.localIdA04199-
dc.contributor.localIdA04268-
dc.contributor.localIdA04268-
dc.relation.journalcodeJ00180-
dc.identifier.eissn2288-6796-
dc.identifier.pmid31183331-
dc.subject.keywordHepatectomy-
dc.subject.keywordHepatocellular carcinoma-
dc.subject.keywordSpontaneous rupture-
dc.subject.keywordTherapeutic chemoembolization-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.affiliatedAuthor김도영-
dc.contributor.affiliatedAuthor김승업-
dc.contributor.affiliatedAuthor김승업-
dc.contributor.affiliatedAuthor김재근-
dc.contributor.affiliatedAuthor김재근-
dc.contributor.affiliatedAuthor박준용-
dc.contributor.affiliatedAuthor박준용-
dc.contributor.affiliatedAuthor안상훈-
dc.contributor.affiliatedAuthor안상훈-
dc.contributor.affiliatedAuthor윤동섭-
dc.contributor.affiliatedAuthor윤동섭-
dc.contributor.affiliatedAuthor최기홍-
dc.contributor.affiliatedAuthor최기홍-
dc.contributor.affiliatedAuthor최진섭-
dc.contributor.affiliatedAuthor최진섭-
dc.contributor.affiliatedAuthor한광협-
dc.contributor.affiliatedAuthor한광협-
dc.citation.volume96-
dc.citation.number6-
dc.citation.startPage275-
dc.citation.endPage282-
dc.identifier.bibliographicCitationANNALS OF SURGICAL TREATMENT AND RESEARCH, Vol.96(6) : 275-282, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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