Cited 1 times in
CHA2DS2-VASc score predicts exercise intolerance in young and middle-aged male patients with asymptomatic atrial fibrillation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김창수 | - |
dc.contributor.author | 김태훈 | - |
dc.contributor.author | 엄재선 | - |
dc.contributor.author | 정보영 | - |
dc.date.accessioned | 2019-12-18T00:18:34Z | - |
dc.date.available | 2019-12-18T00:18:34Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/172971 | - |
dc.description.abstract | Exercise intolerance among the clinical symptoms in patients with atrial fibrillation (AF) has usually been masked by their adjusted life style. We sought to assess the role of CHA2DS2-VASc score to predict exercise intolerance in asymptomatic AF patients, and further examine whether the relationship differs by age and gender. Among the 6,275 participants of the prospective Korean registry of the Comparison study of Drugs for symptom control and complication prevention of Atrial Fibrillation (CODE-AF), 1,080 AF patients who underwent exercise treadmill testing were studied. Exercise intolerance was defined as a peak exercise capacity of 7 metabolic equivalents (METs) or less, and the patients were divided into two groups for the analysis: ≤7 METs (n = 131) and >7 METs (n = 949). Patients with exercise intolerance had a significantly higher CHA2DS2-VASc score than those without (3.1 ± 1.3 vs. 2.0 ± 1.5, p < 0.0001). In the multivariate analysis, a higher CHA2DS2-VASc score (OR 1.54, 95% CI 1.31-1.81, p < 0.0001), corrected QT interval (OR 1.01, 95% CI 1.00-1.02, p = 0.026), and increased left atrial volume index (OR 1.02, 95% CI 1.01-1.03, p = 0.001) were found to be independent predictors of exercise intolerance. The impact of the CHA2DS2-VASc score on exercise intolerance was significant only in male patients aged <65 years (OR 3.30, 95% CI 1.76-6.19, p < 0.0001). The CHA2DS2-VASc score may be a feasible risk assessment tool to predict exercise intolerance, especially in young and middle-aged male patients with asymptomatic AF. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Age Factors | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Asymptomatic Diseases | - |
dc.subject.MESH | Atrial Fibrillation/diagnosis* | - |
dc.subject.MESH | Atrial Fibrillation/pathology | - |
dc.subject.MESH | Atrial Fibrillation/physiopathology* | - |
dc.subject.MESH | Cardiorespiratory Fitness/physiology | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/complications | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/diagnosis | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/pathology | - |
dc.subject.MESH | Diagnostic Techniques, Cardiovascular* | - |
dc.subject.MESH | Exercise Tolerance/physiology* | - |
dc.subject.MESH | Heart Failure/complications | - |
dc.subject.MESH | Heart Failure/diagnosis | - |
dc.subject.MESH | Heart Failure/pathology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypertension/complications | - |
dc.subject.MESH | Hypertension/diagnosis | - |
dc.subject.MESH | Hypertension/pathology | - |
dc.subject.MESH | Ischemic Attack, Transient/complications | - |
dc.subject.MESH | Ischemic Attack, Transient/diagnosis | - |
dc.subject.MESH | Ischemic Attack, Transient/pathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Research Design | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Sex Factors | - |
dc.subject.MESH | Stroke/complications | - |
dc.subject.MESH | Stroke/diagnosis | - |
dc.subject.MESH | Stroke/pathology | - |
dc.subject.MESH | Vascular Diseases/complications | - |
dc.subject.MESH | Vascular Diseases/diagnosis | - |
dc.subject.MESH | Vascular Diseases/pathology | - |
dc.subject.MESH | Young Adult | - |
dc.title | CHA2DS2-VASc score predicts exercise intolerance in young and middle-aged male patients with asymptomatic atrial fibrillation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Preventive Medicine and Public Health (예방의학교실) | - |
dc.contributor.googleauthor | Jeong-Eun Yi | - |
dc.contributor.googleauthor | Young Soo Lee | - |
dc.contributor.googleauthor | Eue-Keun Choi | - |
dc.contributor.googleauthor | Myung-Jin Cha | - |
dc.contributor.googleauthor | Tae-Hoon Kim | - |
dc.contributor.googleauthor | Jin-Kyu Park | - |
dc.contributor.googleauthor | Jung-Myung Lee | - |
dc.contributor.googleauthor | Ki-Woon Kang | - |
dc.contributor.googleauthor | Jaemin Shim | - |
dc.contributor.googleauthor | Jae-Sun Uhm | - |
dc.contributor.googleauthor | Jun Kim | - |
dc.contributor.googleauthor | Changsoo Kim | - |
dc.contributor.googleauthor | Jin-Bae Kim | - |
dc.contributor.googleauthor | Hyung Wook Park | - |
dc.contributor.googleauthor | Boyoung Joung | - |
dc.contributor.googleauthor | Junbeom Park | - |
dc.identifier.doi | 10.1038/s41598-018-36185-7 | - |
dc.contributor.localId | A01042 | - |
dc.contributor.localId | A01085 | - |
dc.contributor.localId | A02337 | - |
dc.contributor.localId | A03609 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 30575764 | - |
dc.contributor.alternativeName | Kim, Chang Soo | - |
dc.contributor.affiliatedAuthor | 김창수 | - |
dc.contributor.affiliatedAuthor | 김태훈 | - |
dc.contributor.affiliatedAuthor | 엄재선 | - |
dc.contributor.affiliatedAuthor | 정보영 | - |
dc.citation.volume | 8 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | e18039 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.8(1) : e18039, 2018 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.