37 99

Cited 0 times in

Serial brain SPECT images in a case of Sydenham chorea

DC FieldValueLanguage
dc.contributor.author남효석-
dc.contributor.author이경열-
dc.contributor.author이병인-
dc.contributor.author이종두-
dc.contributor.author이필휴-
dc.date.accessioned2019-11-26T01:22:26Z-
dc.date.available2019-11-26T01:22:26Z-
dc.date.issued1999-
dc.identifier.issn0003-9942-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/172957-
dc.description.abstractBACKGROUND: The pathophysiological nature of Sydenham chorea (SC) has been presumed to be an autoimmune-mediated inflammatory process. Positron emission tomography in SC has revealed a striatal hypermetabolism that might explain the transient neuronal dysfunction. However, any focal hyperperfusion in the striatum or its related structures has not been demonstrated in previous single photon emission computed tomographic (SPECT) imaging studies, which raised a concern about the pathogenesis of the striatal hypermetabolism. OBJECTIVE: To investigate the cerebral perfusion patterns of the subcortical structures by using serial technetium Tc 99m-ethyl cysteinate dimer SPECT in a case of SC, which may provide a clue for the pathophysiological mechanisms. DESIGN: A case report and serial SPECT studies. CASE PRESENTATION: A girl aged 4 years 3 months showed severe generalized choreic movements with concomitant signs of acute pharyngitis. Results of a laboratory study taken 7 days after the onset of chorea showed elevated antistreptolysin O titer, C-reactive protein levels, and erythrocyte sedimentation rate. Other laboratory data, throat culture, echocardiography, brain magnetic resonance imaging, and electroencephalography did not reveal any abnormalities. Five days after treatment with haloperidol and penicillin, the chorea began to improve slowly, and completely resolved in 2 months. RESULTS: Three serial SPECT images and semiquantitative analysis of cerebral perfusion were obtained. Cerebral perfusion in the striatum and thalamus was markedly increased bilaterally during the stage of active chorea and then returned nearly to its baseline level during the convalescent phase. These cerebral perfusion patterns were concordant with semiquantitative analysis. CONCLUSIONS: Hyperperfusion in both the striatum and thalamus in our patient may reflect the subcortical inflammatory processes in SC. The unequivocal SPECT findings in our patient are difficult to reconcile with the negative findings of previous SPECT studies but may suggest the heterogeneity of the perfusion patterns in SC.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherAmerican Medical Association-
dc.relation.isPartOfARCHIVES OF NEUROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleSerial brain SPECT images in a case of Sydenham chorea-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorPhil Hyu Lee-
dc.contributor.googleauthorHyo Suk Nam-
dc.contributor.googleauthorKyung Yul Lee-
dc.contributor.googleauthorByung In Lee-
dc.contributor.googleauthorJong Doo Lee-
dc.identifier.doi10.1001/archneur.56.2.237-
dc.contributor.localIdA01273-
dc.contributor.localIdA02648-
dc.contributor.localIdA02648-
dc.contributor.localIdA02797-
dc.contributor.localIdA02797-
dc.contributor.localIdA03138-
dc.contributor.localIdA03138-
dc.contributor.localIdA03270-
dc.contributor.localIdA03270-
dc.relation.journalcodeJ00223-
dc.identifier.eissn1538-3687-
dc.identifier.pmid10025430-
dc.contributor.alternativeNameNam, Hyo Suk-
dc.contributor.affiliatedAuthor남효석-
dc.contributor.affiliatedAuthor이경열-
dc.contributor.affiliatedAuthor이경열-
dc.contributor.affiliatedAuthor이병인-
dc.contributor.affiliatedAuthor이병인-
dc.contributor.affiliatedAuthor이종두-
dc.contributor.affiliatedAuthor이종두-
dc.contributor.affiliatedAuthor이필휴-
dc.contributor.affiliatedAuthor이필휴-
dc.citation.volume56-
dc.citation.number2-
dc.citation.startPage237-
dc.citation.endPage240-
dc.identifier.bibliographicCitationARCHIVES OF NEUROLOGY, Vol.56(2) : 237-240, 1999-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.