Cited 22 times in
Behçet's disease sera containing antiendothelial cell antibodies promote adhesion of T lymphocytes to cultured human dermal microvascular endothelial cells
DC Field | Value | Language |
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dc.contributor.author | 방동식 | - |
dc.contributor.author | 이광훈 | - |
dc.date.accessioned | 2019-11-26T01:15:32Z | - |
dc.date.available | 2019-11-26T01:15:32Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/172870 | - |
dc.description.abstract | Antiendothelial cell antibodies (AECA) have been detected in the sera of patients of autoimmune diseases showing vasculitis. Using IgM-ELISA, we found AECA in 42 (56%) of 75 sera samples from patients with Behçet's disease in a previous study. All of the 15 AECA-positive sera of Behçet's disease patients had an increased expression of the intercellular cell adhesion molecule-1 (ICAM-1), 93.3% of the sera induced the vascular cell adhesion molecule-1 (VCAM-1), and 100% of the serum induced the E-selectin molecule on human dermal microvascular endothelial cells (HDMEC). After stimulation of HDMEC with AECA-positive sera of Behçet's disease patients, the expression of ICAM-1 and VCAM-1 on HDMEC increased significantly at 4 hours, reaching a peak at 16 hours. Expression of E-selectin was induced at 1 hour after stimulation with a peak at 4 hours and it decreased thereafter. Adherence of T lymphocytes to HDMEC increased significantly after stimulation with AECA-positive sera from Behçet's disease patients. Also, the adherence of T lymphocytes to HDMEC increased at 4 hours and returned to its normal level at 48 hours. These results show that AECA-positive sera of Behçet's disease patients are capable of activating HDMEC to promote the adherence of T lymphocytes to increase the expression of ICAM-1, VCAM-1, and E-selectin on the cell surfaces. The whole process may play an important role in the pathogenesis of vasculitis in Behçet's disease. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Antibodies/blood | - |
dc.subject.MESH | Antibodies/physiology* | - |
dc.subject.MESH | Behcet Syndrome/blood* | - |
dc.subject.MESH | Behcet Syndrome/immunology | - |
dc.subject.MESH | Blood Physiological Phenomena | - |
dc.subject.MESH | Cell Adhesion/physiology | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Endothelium, Vascular/cytology | - |
dc.subject.MESH | Endothelium, Vascular/immunology* | - |
dc.subject.MESH | Endothelium, Vascular/physiology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Microcirculation/physiology | - |
dc.subject.MESH | Skin/blood supply* | - |
dc.subject.MESH | T-Lymphocytes/physiology* | - |
dc.title | Behçet's disease sera containing antiendothelial cell antibodies promote adhesion of T lymphocytes to cultured human dermal microvascular endothelial cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학교실) | - |
dc.contributor.googleauthor | Kwang Hoon Lee | - |
dc.contributor.googleauthor | Hae Shin Chung | - |
dc.contributor.googleauthor | Dongsik Bang | - |
dc.contributor.googleauthor | Sungnack Lee | - |
dc.identifier.doi | 10.3349/ymj.1999.40.2.152 | - |
dc.contributor.localId | A01784 | - |
dc.contributor.localId | A02674 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 10333719 | - |
dc.contributor.alternativeName | Bang, Dong Sik | - |
dc.contributor.affiliatedAuthor | 방동식 | - |
dc.contributor.affiliatedAuthor | 이광훈 | - |
dc.citation.volume | 40 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 152 | - |
dc.citation.endPage | 158 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.40(2) : 152-158, 1999 | - |
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