Cited 4 times in
The loss of expression of transforming growth factor-β receptors correlates with the histopathologic tumor grade in bladder transitional cell carcinoma patients
DC Field | Value | Language |
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dc.contributor.author | 정병하 | - |
dc.contributor.author | 홍성준 | - |
dc.date.accessioned | 2019-11-26T01:09:59Z | - |
dc.date.available | 2019-11-26T01:09:59Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/172794 | - |
dc.description.abstract | Transforming growth factor-beta (TGF-beta), a pleiotropic growth factor, is a potent inhibitor of cellular proliferation in cells of epithelial origin. Recently, it has been suggested that a loss of sensitivity to TGF-beta through a loss of expression of TGF-beta receptors T beta R-I and T beta R-II--is associated with tumor initiation and progression. Therefore, to investigate the relationship between TGF-beta receptors expression and carcinogenesis of bladder TCC, this study examined the expression of T beta R-I and T beta R-II in 46 bladder TCC patients using immunohistochemistry. Since histopathological grade is a widely accepted marker of prognosis, the results were compared in relation to the three grades of bladder TCC. The results demonstrated that the loss of TGF-beta receptors expression is associated with increasing histopathological grades of bladder TCC. Specifically, both T beta R-I and T beta R-II were readily detected in all 10 normal bladder mucosa specimens. Likewise, all 6 specimens of grade I TCC samples expressed high levels of both TGF-beta receptors. However, among grade II TCC samples, T beta R-I and T beta R-II were detected in 78% and 89%, respectively: among grade III TCC samples, T beta R-I and T beta R-II were detected in 45% and 41%, respectively. These results suggested that loss of sensitivity to TGF-beta may play a role in the progression of TCC from low to high grade disease. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Carcinoma, Transitional Cell/metabolism* | - |
dc.subject.MESH | Carcinoma, Transitional Cell/pathology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Receptors, Transforming Growth Factor beta/metabolism* | - |
dc.subject.MESH | Reference Values | - |
dc.subject.MESH | Urinary Bladder Neoplasms/metabolism* | - |
dc.subject.MESH | Urinary Bladder Neoplasms/pathology* | - |
dc.title | The loss of expression of transforming growth factor-β receptors correlates with the histopathologic tumor grade in bladder transitional cell carcinoma patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨의학교실) | - |
dc.contributor.googleauthor | Dong Hyeon Lee | - |
dc.contributor.googleauthor | Seung Choul Yang | - |
dc.contributor.googleauthor | Sung Joon Hong | - |
dc.contributor.googleauthor | Byung Ha Chung | - |
dc.contributor.googleauthor | Hyun Jik Chung | - |
dc.contributor.googleauthor | Hideo Tokunaga | - |
dc.contributor.googleauthor | Issac Y Kim | - |
dc.contributor.googleauthor | Yun S Song | - |
dc.contributor.googleauthor | Seth P Lerner | - |
dc.contributor.googleauthor | Ronald A Morton | - |
dc.identifier.doi | 10.3349/ymj.1999.40.2.118 | - |
dc.contributor.localId | A03607 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 10333714 | - |
dc.contributor.alternativeName | Chung, Byung Ha | - |
dc.contributor.affiliatedAuthor | 정병하 | - |
dc.citation.volume | 40 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 118 | - |
dc.citation.endPage | 123 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.40(2) : 118-123, 1999 | - |
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