Cited 4 times in
Effects of Long-acting Somatostatin Analogue(Sandostatin) on Manifest Diabetic Ketoaidosis.
DC Field | Value | Language |
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dc.contributor.author | 이현철 | - |
dc.date.accessioned | 2019-11-26T01:09:18Z | - |
dc.date.available | 2019-11-26T01:09:18Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 1056-8727 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/172786 | - |
dc.description.abstract | Insulin deficiency and counterregulatory hormone excess are the basic process in the development of diabetic ketoacidosis (DKA). Somatostatin, which suppresses the secretion of glucagon and growth hormone, has been known to attenuate the rate of gluconeogesis and ketogenesis in insulin-dependent diabetes mellitus patients. However, the therapeutic efficacy of somatostatin has not been approved to be practical in the treatment of manifest DKA. To examine the additive effect of octreotide, the synthetic long-acting somatostatin analogue SMS 201-995, to conventional treatment of manifest DKA, we compared the correction time of acidosis, ketonuria, and hyperglycemia of patients treated with an intravenous infusion of low-dose insulin (4 units per hour) plus subcutaneous injection of octreotide (50 microg every 6 hours) by low-dose insulin alone. The correction time for hyperglycemia and acidosis did not show any difference between groups (p = 0.089, p = 0.82). However, the time for disappearance of ketonuria of the octreotide-treated group (38.0 +/- 32.0 h) was reduced significantly compared to other group (68.3 +/- 26.0 h) (p = 0.048). These results indicated that the addition of octreotide to conventional treatment of DKA might improve the correction of ketosis, but would not allow more rapid control of acidosis and hyperglycemia in manifest DKA. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science Pub. Co. | - |
dc.relation.isPartOf | Journal of Diabetes and Its Complications | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Blood Glucose/metabolism | - |
dc.subject.MESH | C-Peptide/blood | - |
dc.subject.MESH | Diabetic Ketoacidosis/blood | - |
dc.subject.MESH | Diabetic Ketoacidosis/drug therapy* | - |
dc.subject.MESH | Diabetic Ketoacidosis/urine | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hormones/therapeutic use* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hyperglycemia | - |
dc.subject.MESH | Hypoglycemic Agents/administration & dosage | - |
dc.subject.MESH | Hypoglycemic Agents/therapeutic use | - |
dc.subject.MESH | Infusions, Intravenous | - |
dc.subject.MESH | Insulin/administration & dosage | - |
dc.subject.MESH | Insulin/therapeutic use | - |
dc.subject.MESH | Ketone Bodies/urine | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Octreotide/therapeutic use* | - |
dc.subject.MESH | Time Factors | - |
dc.title | Effects of Long-acting Somatostatin Analogue(Sandostatin) on Manifest Diabetic Ketoaidosis. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Yong Seok Yun | - |
dc.contributor.googleauthor | Hyun Chul Lee | - |
dc.contributor.googleauthor | Chong Seok Park | - |
dc.contributor.googleauthor | Kyung Hee Chang | - |
dc.contributor.googleauthor | Chae Hwa Cho | - |
dc.contributor.googleauthor | Young Duk Song | - |
dc.contributor.googleauthor | Sung Kil Lim | - |
dc.contributor.googleauthor | Kyung Rae Kim | - |
dc.contributor.googleauthor | Kap Bum Huh | - |
dc.identifier.doi | 10.1016/s1056-8727(99)00059-8 | - |
dc.contributor.localId | A03301 | - |
dc.relation.journalcode | J01376 | - |
dc.identifier.eissn | 1873-460X | - |
dc.identifier.pmid | 10765004 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1056872799000598 | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | 이현철 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 5~6 | - |
dc.citation.startPage | 288 | - |
dc.citation.endPage | 292 | - |
dc.identifier.bibliographicCitation | Journal of Diabetes and Its Complications, Vol.13(5~6) : 288-292, 1999 | - |
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