0 316

Cited 14 times in

Spontaneous apoptosis as a predictor of radiotherapy in patients with stage IIB squamous cell carcinoma of the uterine cervix.

DC Field Value Language
dc.contributor.author성진실-
dc.contributor.author양우익-
dc.date.accessioned2019-11-26T01:06:24Z-
dc.date.available2019-11-26T01:06:24Z-
dc.date.issued1999-
dc.identifier.issn0284-186X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/172741-
dc.description.abstractThe purpose of this study was to investigate the correlation between the spontaneous apoptotic index (SAI) determined from pretreatment biopsy specimens with the various clinical outcomes of patients with FIGO stage IIB squamous cell carcinoma of the uterine cervix in a retrospective analysis. Forty-eight patients treated with curative radiotherapy between 1989 and 1993 were evaluated. Pretreatment biopsy specimens of those patients were scored for apoptosis, mitosis, and proliferating cell nuclear antigen (PCNA) immunohistochemical staining. The range of the SAI was 0.2-4.7% (median 1.1%). Patients whose tumours had a SAI above the median had better local control (p = 0.0062) and overall survival (p = 0.0053) than those with a lower SAI. Furthermore, the SAI was marginally significant on local control by a multivariate Cox regression analysis (p = 0.0571). There was no correlation between the SAI and proliferation (mitosis and PCNA).-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherInforma Healthcare-
dc.relation.isPartOfACTA ONCOLOGICA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHApoptosis/physiology*-
dc.subject.MESHBiopsy-
dc.subject.MESHCarcinoma, Squamous Cell/pathology-
dc.subject.MESHCarcinoma, Squamous Cell/radiotherapy*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHUterine Cervical Neoplasms/pathology-
dc.subject.MESHUterine Cervical Neoplasms/radiotherapy*-
dc.titleSpontaneous apoptosis as a predictor of radiotherapy in patients with stage IIB squamous cell carcinoma of the uterine cervix.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학교실)-
dc.contributor.googleauthorChung EJ-
dc.contributor.googleauthorSeong J-
dc.contributor.googleauthorYang WI-
dc.contributor.googleauthorPark TK-
dc.contributor.googleauthorKim JW-
dc.contributor.googleauthorSuh CO-
dc.contributor.googleauthorKim GE-
dc.identifier.doi10.1080/028418699431979-
dc.contributor.localIdA01956-
dc.contributor.localIdA02300-
dc.relation.journalcodeJ00024-
dc.identifier.eissn1651-226X-
dc.identifier.pmid10418711-
dc.identifier.urlhttps://www.tandfonline.com/doi/abs/10.1080/028418699431979-
dc.contributor.alternativeNameSeong, Jin Sil-
dc.contributor.affiliatedAuthor성진실-
dc.contributor.affiliatedAuthor양우익-
dc.citation.volume38-
dc.citation.number4-
dc.citation.startPage449-
dc.citation.endPage454-
dc.identifier.bibliographicCitationACTA ONCOLOGICA, Vol.38(4) : 449-454, 1999-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.