고용량 cytosine arabnosie 화학요법후 발생한 대뇌중후군

Abstract

Cytosine arabinoside(Ara-C) is a highly active agent in the treatment of acute leukemia and malignant lymphoma. The usa of high-dose Ara-C therapy has been advanced as a possible means of overcoming resistance. High dose Ara-C regimens are occasionally associated with cerebellar and cerebral toxicities while toxicities in conventional doss regimens are mainly restricted to the bone marrow and gastrolntestlnal tract. A 21-year-old male patient with acute lymphoblastic leukemia in second rslapse developed cerebral syndrome 10 days after high-dose Ara-C chemotherapy. We present a case of acute cerebral toxicity after high dose Ara-C chemotherapy with relevant literature review.