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국산 해파리 부착 스텐트의 돼지 관상동맥 스텐트 재협착에 대한 효과
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2019-11-26T01:02:01Z | - |
dc.date.available | 2019-11-26T01:02:01Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 1738-5520 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/172679 | - |
dc.description.abstract | Background : Stent thrombosis and late restenosis are still major limitations in the clinical use of coronary stenting. Heparin-coated stent may reduce the incidences of stent thrombosis and restenosis. Heparin-coated stents were compared with control stents in a porcine coronary stent restenosis model in order to evaluate the effects of heparin-coated stent on stent restenosis. Methods : Heparin was coated on a stent by deposition of an ultra-thin polymeric film containing amine groups by means of plasma polymerization. And then stent was immersed in heparin solution. Stent overdilation injury (stent:artery=1.3:1.0) was performed with bare (Group I, n=4) and heparin-coated (Group II, n=5) MAC stents in porcine coronary arteries. Follow-up quantitative coronary angiography (QCA) was performed at 4 weeks after stenting. The histopathologic assessments (KERN=*)of stented porcine coronary arteries were compared in between 2 groups. Results : 1)Luminal area of stented artery was 7.05±1.25 mm2 in Group I and 7.67±2.85 mm2 in Group II, which were not different between two Groups. 2)Histopathologic stenosis of Group I was 35.7±13.2%, which was higher than 28.6±14.7% of Group II (p<0.05). Ratio of neointima/media was 1.16±0.52 in Group I and 0.87±0.31 in Group II and neointimal area was higher in Group I than in Group II (3.81±1.78 mm2 vs. 2.82±1.11 mm2, p<0.05 respectively). 3)PCNA (Proliferating cell nuclear antigen) index of GroupI was 10.0±2.2%, which was higher than in Group II (6.8±4.0%). Conclusions : Heparin-coated MAC stent may be effective in the inhibition of neointimal proliferation in a porcine stent restenosis model. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한심장학회 | - |
dc.relation.isPartOf | Korean Circulation Journal (순환기) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 국산 해파리 부착 스텐트의 돼지 관상동맥 스텐트 재협착에 대한 효과 | - |
dc.title.alternative | The Effects of the Heparin-Coated Maximum Arterial Re-Creation (MAC) Stent on Porcine Coronary Stent Restenosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | 박형욱 | - |
dc.contributor.googleauthor | 정명호 | - |
dc.contributor.googleauthor | 장양수 | - |
dc.contributor.googleauthor | 김용록 | - |
dc.contributor.googleauthor | 김완 | - |
dc.contributor.googleauthor | 박우석 | - |
dc.contributor.googleauthor | 김남호 | - |
dc.contributor.googleauthor | 김준우 | - |
dc.contributor.googleauthor | 김성희 | - |
dc.contributor.googleauthor | 조장현 | - |
dc.contributor.googleauthor | 안영근 | - |
dc.contributor.googleauthor | 조정관 | - |
dc.contributor.googleauthor | 조동련 | - |
dc.contributor.googleauthor | 김현진 | - |
dc.contributor.googleauthor | 박종춘 | - |
dc.contributor.googleauthor | 이재혁 | - |
dc.contributor.googleauthor | 박창수 | - |
dc.contributor.googleauthor | 강정채 | - |
dc.identifier.doi | 10.4070/kcj.1999.29.5.498 | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J01953 | - |
dc.identifier.eissn | 1738-5555 | - |
dc.subject.keyword | Heparin-coated stent | - |
dc.subject.keyword | Stent Restenosis | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | 장양수 | - |
dc.citation.volume | 29 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 498 | - |
dc.citation.endPage | 506 | - |
dc.identifier.bibliographicCitation | Korean Circulation Journal (순환기), Vol.29(5) : 498-506, 1999 | - |
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