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유방암 환자의 혈액 및 암조직에서 생물학적 치료의 Target으로서 Urokinase-type Plasminogen Activator(uPA), uPA Receptor, Plasminogen Activator Inhibitor-1의 발현.
DC Field | Value | Language |
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dc.contributor.author | 노재경 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 정현철 | - |
dc.date.accessioned | 2019-11-26T01:01:19Z | - |
dc.date.available | 2019-11-26T01:01:19Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0496-6872 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/172670 | - |
dc.description.abstract | Purpose: We measured and compared the uPA, plasminogen activator inhibitor-1 (PAI-1) and uPA receptor (uPAR) levels in breast cancer tissues and blood of the patients to evaluate their clinical relevance for biotherapy. Materials and Methods: uPA, PAI-1 (Monozyme, Netherland), uPAR (American Diag- nostics, USA) levels were measured by ELISA assay in 192 breast cancer tissues, in 18 normal breast tissues and in 163 blood from breast cancer patients. Results: There was a tendency of uPA increment from ductal carcinoma in situ while increment of PAI-1 and uPAR occurred from Ti. With the progression of cancer, uPA, PAI-1, uPAR tended to decrease; however, the uPA/uPAR, uPA/PAI-1 ratios remained unchanged. There was a correlation of uPA expression between normal and cancer tissues ( r(2)= 0.49). Correlation of uPA and PAI-1 was found in normal tissue and stage I cancer tissue while correlation of uPAR and PAI-1 was found with cancer progression. Between cancer tissue and blood significant correlations were found in uPA, PAI-1, uPAR levels. Conclusion: uPA, PAI-1, uPAR levels in cancer tissue elevated from the early stage maintaining correlative expressions with cancer progression. A positive correlation between cancer tissue and blood level suggested the applicability of the levels of uPA, PAI-1 or uPAR for detecting patients for biotherapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한암학회 | - |
dc.relation.isPartOf | Journal of the Korean Cancer Association (대한암학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 유방암 환자의 혈액 및 암조직에서 생물학적 치료의 Target으로서 Urokinase-type Plasminogen Activator(uPA), uPA Receptor, Plasminogen Activator Inhibitor-1의 발현. | - |
dc.title.alternative | Clinical Relevance of Urokinase-type Plasminogen Activator ( uPA ) , uPA Receptor , Plasminogen Activator Inhibitor-1 Co-expression from Tissue and Serum of Breast Cancer as Targets of Biotherapy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | 라선영 | - |
dc.contributor.googleauthor | 박준오 | - |
dc.contributor.googleauthor | 공수정 | - |
dc.contributor.googleauthor | 박세호 | - |
dc.contributor.googleauthor | 유내춘 | - |
dc.contributor.googleauthor | 양우익 | - |
dc.contributor.googleauthor | 노재경 | - |
dc.contributor.googleauthor | 민진식 | - |
dc.contributor.googleauthor | 이경식 | - |
dc.contributor.googleauthor | 김병수 | - |
dc.contributor.googleauthor | 정현철 | - |
dc.contributor.localId | A01290 | - |
dc.contributor.localId | A01316 | - |
dc.contributor.localId | A03773 | - |
dc.relation.journalcode | J01813 | - |
dc.subject.keyword | uPA, uPAR, PAI-1, Breast cancer, Tissue, Blood | - |
dc.contributor.alternativeName | Roh, Jae Kyung | - |
dc.contributor.affiliatedAuthor | 노재경 | - |
dc.contributor.affiliatedAuthor | 라선영 | - |
dc.contributor.affiliatedAuthor | 정현철 | - |
dc.citation.volume | 31 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 256 | - |
dc.citation.endPage | 266 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Cancer Association (대한암학회지), Vol.31(2) : 256-266, 1999 | - |
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